SSRIs A pharmacological cul-de-sac -- Neurobiology of SSRI withdrawal -- Pramipexole in the treatment of depression -- Opioid mechanisms in the treatment of depression -- Neuropsychological effects of antidepressants-translational studies -- KETAMINE FOR MAJOR DEPRESSIVE DISORDER -- Psilocybin and other classic psychedelics in depression -- Gut-brain axis and antidepressant treatment -- Anti-inflammatory drugs in the treatment of depression -- Mechanisms of TMS in Depression -- Mechanism of action of ECT in depression -- Vagal nerve stimulation in the treatment of depression.

This volume is unique in bringing the exciting range of antidepressant treatment developments together with a focus on their neurobiological mechanisms and how these interact with the known pathophysiology of depression. Current evidence for treatment efficacy is reviewed together with a discussion of where in the management pathway of this common condition, these new approaches might take their place.