Part I: Meningioma Pathology and Population-Based Aspects -- 1: Meningiomas in Children -- 2: Meningiomas in the Elderly -- 3: Meningiomas and Hormone-Related Clinical Conditions -- 4: Meningiomas in Genetic and Familial Syndromes: Biomolecular Correlations -- Part II: Meningiomas: Pathological – Clinical Correlations -- 5: Meningiomas Development: Meningeal Embryology and Tumorigenesis -- 6: Molecular Biology and Genetics of Meningiomas: Classification and diagnostic methods -- 7: Comprehensive Overview of Genetic Alterations in Meningioma -- 8: Meningioma Location: Pathological – Prognostic Correlations -- 9: Brain - Tumor Interface, Brain Invasion and Peritumoral edema in Meningiomas: Pathological - Clinical Implications -- 10: Malignant Meningiomas -- Part III : Meningioma Pathology and Imaging -- 11: Pathology – Imaging Correlations of Meningiomas: Imaging Mimics -- 12: Radiomics in Meningiomas: Pathological and Biomolecular Correlation -- 13: PET and SPECT in Meningiomas: Pathological Correlations -- Part IV : Meningioma Pathology and Management -- 14: The Simpson Grading: Is it Still Valid after WHO Classification in the Imaging Era? -- 15: Aggressive Versus more Conservative Surgery for Invasive Meningiomas -- 16: Meningioma Pathology and Radiotherapy at Initial Diagnosis -- 17: Biomolecular-Related Medical Therapies for Meningiomas -- Part V : Meningioma Pathology and Recurrences -- 18: Time to Recurrence of Meningiomas -- 19: Topography of Meningioma Recurrences: Localized versus Diffuse -- 20: Management of Recurrences of Non-Skull Base Meningiomas -- 21: Management of Recurrences of Skull Base Meningiomas -- 22: Multiple Re-operations for Recurrent Meningiomas.

This book aims to explore the correlation between pathology and molecular biology with the clinical and diagnostic features, management, and outcome of meningiomas. With its unique structure consisting of 6 parts and 22 chapters, it provides a comprehensive analysis of this topic. Each chapter delves into the pathological features, emphasizing their clinical implications, making this book distinct from others in its field. Several topics discussed in this book are not found in other texts. These include the hormone-related clinical factors, the clinical impact of the 2021 WHO Classification of tumors of the CNS, the clinical and prognostic role of hormone-receptor expression, the pattern of dural invasion, the brain-tumor interface and brain invasion, and the radiomics. Part I serves as an introduction, focusing on the most recent research on the origin and growth of meningiomas. Part II explores the various aspects and the correlation of meningioma occurrence within the general population. Part III centers around the clinical impact of macroscopic, histological, and biomolecular features of meningiomas. Part IV is dedicated to imaging diagnosis, including a chapter on radiomics, a novel and sophisticated imaging technique not covered in other texts. Part V examines the impact of pathology on the management of meningiomas, encompassing modern radiotherapeutic and biomolecular targeted therapies. Finally, Part VI delves into meningioma recurrence, with a unique chapter on the topography of recurrences, a topic not extensively discussed in other books. The primary audience for this book includes neurooncologists, neurosurgeons, radiotherapists, neuroradiologists, pathologists with a focus on molecular biology, as well as neurologists and geneticists. It serves as a valuable resource for professionals in these fields, providing in-depth insights into the correlation between pathology, molecular biology, and the clinical aspects of meningiomas.