"Version: 20230401"--Title page verso.

Includes bibliographical references.

1. Introduction -- 1.1. Early developments of biomedical engineering -- 1.2. Modelling in biomedical engineering -- 1.3. Modelling approaches in biomedical engineering

2. Mechanistic modelling -- 2.1. Background -- 2.2. Fundamentals of mechanistic modelling -- 2.3. Ocular heat transfer : an illustrative example -- 2.4. Important considerations in mechanistic modelling -- 2.5. Summary

3. Review of the finite element method -- 3.1. Introduction -- 3.2. Weighted residual method -- 3.3. Finite element method -- 3.4. Finite element mesh -- 3.5. Trial basis (shape) functions -- 3.6. Galerkin finite element method -- 3.7. Mesh convergence -- 3.8. Finite element method with COMSOL Multiphysics -- 3.9. Summary

4. Heat transfer in biological tissues -- 4.1. Introduction -- 4.2. Thermoregulation -- 4.3. Bioheat transfer -- 4.4. Hyperthermia -- 4.5. Thermal therapy -- 4.6. Thermal damage -- 4.7. General summary

5. Haemodynamics -- 5.1. Introduction -- 5.2. Arteries, veins, and capillaries -- 5.3. Physical properties of blood -- 5.4. Haemodynamics of a single blood vessel -- 5.5. Computational fluid dynamics in blood flow analysis -- 5.6. Blood flow in capillaries -- 5.7. General summary

6. Mass transport in biological tissues -- 6.1. Introduction -- 6.2. Fick's law of diffusion -- 6.3. Convection-diffusion equation -- 6.4. Transvascular fluid exchange -- 6.5. Interstitial fluid flow -- 6.6. Drug delivery -- 6.7. Dual porosity model -- 6.8. General summary

7. Physiological modelling and data analytics -- 7.1. Fundamentals of physiological modelling -- 7.2. Theories of model fitting and linear regression -- 7.3. Data analytics and interpretation -- 7.4. Summary

8. Glucose-insulin system -- 8.1. Human endocrine system and the pancreas -- 8.2. Glucose level regulation and diabetes mellitus -- 8.3. Model for human glucose-insulin interaction -- 8.4. Application of glucose-insulin models in regulating glucose level -- 8.5. Summary

9. Respiratory system -- 9.1. Function of the human respiratory system -- 9.2. The mechanics of breathing -- 9.3. Respiratory system models -- 9.4. Application of respiratory system models -- 9.5. Summary

10. Cardiovascular system -- 10.1. The human cardiovascular system -- 10.2. Cardiac cycle -- 10.3. Cardiovascular disease and circulatory shock -- 10.4. Cardiovascular system modelling -- 10.5. Application of the human cardiovascular system -- 10.6. Summary

11. Ethics and biosafety -- 11.1. Introduction -- 11.2. Human ethics -- 11.3. Biosafety -- 11.4. Summary -- Appendix A. Review on heat transfer.

The advent of high-performance computing has benefited various disciplines including healthcare. Enhanced computational capabilities have helped biomedical engineers reach practical solutions to sophisticated and complex biophysical and physiological problems. This book addresses two leading model-based approaches, including, mechanistic modelling and physiological modelling, and their applications in biomedical engineering. Various topics in healthcare and medicine, their comprehension through ordinary and partial differential equations and their solution utilizing appropriate numerical strategy are considered. The text is divided into two parts. Part I of the book explores the concept and application of mechanistic modelling, while Part II deals with content relevant to physiological modelling. This practical guide is a key text for undergraduate students studying biomedical engineering and researchers in the field of biomedical engineering and healthcare. Part of IPEM-IOP Series in Physics and Engineering in Medicine and Biology.

Undergraduate, graduate and postgraduate students who are majoring in biomedical engineering. Students from clinical and medical fields with the appropriate mathematical background may also find the book useful. Expert and novice researchers wanting to explore computational modelling in biomedical engineering. Researchers working in healthcare systems, computer aided diagnosis of diseases, universities with applied mathematics departments, research hospitals.

Also available in print.

Mode of access: World Wide Web.

System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.

Ean Hin Ooi is an Associate Professor at Monash University Malaysia. He is an Associate Editor for the journal Computer Methods and Programs in Biomedicine and Journal of Mechanics in Medicine and Biology. He is also a technical consultant for Ascend Technologies Ltd, United Kingdom. He has published 71 refereed journal papers, 14 conference proceedings and 8 book chapters. Yeong Shiong Chiew is a Senior Lecturer at Monash University Malaysia, as well as a visiting researcher at the University of Liege, Belgium. He is an Academic Editor for Biomed Research International and BMC Pulmonary Medicine. He has published 61 refereed journal articles, and more than 100 conference papers and abstracts, largely dealing with various modelling aspects in biomedical engineering.

Title from PDF title page (viewed on May 2, 2023).