PROTAC-Mediated Protein Degradation: A Paradigm Shift in Cancer Therapeutics (Record no. 63005)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04222nam a22006015i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-981-97-5077-1 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20251030112930.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240901s2024 si | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9789819750771 |
| -- | 978-981-97-5077-1 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-981-97-5077-1 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RS400-431 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | PSB |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | SCI013040 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | PNB |
| Source | thema |
| 245 10 - TITLE STATEMENT | |
| Title | PROTAC-Mediated Protein Degradation: A Paradigm Shift in Cancer Therapeutics |
| Medium | [electronic resource] / |
| Statement of responsibility, etc. | edited by Mukesh Nandave, Priti Jain. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. 2024. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Singapore : |
| Name of producer, publisher, distributor, manufacturer | Springer Nature Singapore : |
| -- | Imprint: Springer, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | XXII, 385 p. 68 illus., 55 illus. in color. |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS | |
| File type | text file |
| Encoding format | |
| Source | rda |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 1. Understanding the Ubiquitin Proteasome System - History and Revolution -- 2. PROTACs: Principles and Mechanisms -- 3. Structural Considerations and Chemistry of PROTAC -- 4. Advantages and Disadvantages of PROTACs -- 5. Novel Technologies in PROTAC Design -- 6. Future of trends in the design and development of PROTAC -- 7. Global Regulatory Requirements Applicable for PROTACs -- 8. Tissue-Specific Targeting Strategies with PROTAC Technology -- 9. Clinical Development OF PROTACs -- 10. Toxicological Aspects of PROTACs -- 11. PROTACs in the management of Prostate Cancer -- 12. Exploring the Role of PROTACs for the Treatment of Breast Cancer -- 13. Role of PROTACs in Hematological Malignancies -- 14. Artificial Intelligence and Machine Learning for Exploring PROTAC in Underutilized Cells -- 15. PROTACs in Treatment of Glioma -- 16. Proteolysis Targeting Chimera (PROTACs) an Attractive Technology in CVD Therapeutics: Opportunities and Challenges -- 17. Delivery systems - miniaturised PROTAC, Nano PROTAC, Aptamer-based RNA PROTAC. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This book is a comprehensive coverage of the ubiquitin-proteasome system and its involvement in cancer progression, and the application of PROTACs in different types of cancer treatment. The book discusses a unique perspective and comprehensive knowledge of the potential of PROTACs to transform cancer therapies. It provides an overview of the history, mechanisms, chemistry, design considerations, and different technologies involved in PROTACs. Additionally, it explains the ubiquitin-proteasome system, its impact on various diseases, and the principles and mechanisms of UPS. The book also describes the chemistry and design aspects of PROTACs and their role in various types of cancers. Finally, it covers the pharmaceutics aspect of formulation design, global requirements, and toxicological aspects of PROTACs. This book is targeted at cancer researchers, medical oncologists, bioinformatics, computational biologists, pharmacologists, medicinal chemists, formulation scientists, regulatory authorities, and policy makers. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
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| 9 (RLIN) | 67844 |
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| Topical term or geographic name as entry element | |
| 9 (RLIN) | 74275 |
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| Topical term or geographic name as entry element | |
| 9 (RLIN) | 70760 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | |
| 9 (RLIN) | 64666 |
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| Topical term or geographic name as entry element | |
| 9 (RLIN) | 67846 |
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| Topical term or geographic name as entry element | |
| 9 (RLIN) | 67844 |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | |
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| Topical term or geographic name as entry element | |
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| Topical term or geographic name as entry element | |
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| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | |
| 9 (RLIN) | 64666 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nandave, Mukesh. |
| Relator term | editor. |
| Relator code | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 9 (RLIN) | 74724 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jain, Priti. |
| Relator term | editor. |
| Relator code | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 9 (RLIN) | 83504 |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer Nature eBook |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9789819750764 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9789819750788 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9789819750795 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1007/978-981-97-5077-1">https://doi.org/10.1007/978-981-97-5077-1</a> |
| 912 ## - | |
| -- | ZDB-2-SME |
| 912 ## - | |
| -- | ZDB-2-SXM |
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