Handbook for chemical process research and development /
Chemical process research and development
authored by Wenyi Zhao, Senior Research Scientist, Jacobus Pharmaceutical Company, Princeton.
- Second edition.
- 1 online resource (xxxix, 825 pages) : illustrations
Includes bibliographical references and index.
1. Reaction solvent selection2. Reagent selection3. Various reagent surrogates4. Modes of reagent addition -control of impurity formation5. Process optimization with additives6. Process optimization of catalytic reactions7. Process optimization of problematic reactions8. Hazards of oxidation and reduction reactions9. Other hazardous reactions10. Hazardous reagents11. Grignard reagent and related reactions12. Challenging reaction intermediates13. Protecting groups14. Telescope approach15. Design of new synthetic route16. Stereochemistry17. Various quenching strategies18. Various isolation and purification strategies19. Methods for residual metal removal20. Methods for impurity removal21. Pharmaceutical salts22. Solid form
"This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies"--