04815nam a2200745 i 4500 on1365767404 EBZ 20251029164105.0 m d cr cnu---unuuu 221125t20232023flua obf 001 0 eng 2022047641 EBZ eng EBZ GBC321757 bnb 020941586 Uk 9781003288411 electronic book 1003288413 electronic book 9781000859010 electronic book 1000859010 electronic book 9781000859058 electronic book 1000859053 electronic book 9781032259277 hardcover 9781032264615 paperback 9781003288411 10.1201/9781003288411 doi 9781003288411 Taylor & Francis pcc RM301.25 .Z44 2023 SCI 013060 bisacsh TEC 009010 bisacsh MED 071000 bisacsh TD bicssc MAIN Zhao, Wenyi (Chemist), author. 64803 Handbook for chemical process research and development / authored by Wenyi Zhao, Senior Research Scientist, Jacobus Pharmaceutical Company, Princeton. Chemical process research and development Second edition. Boca Raton, FL : CRC Press, 2023. ©2023 1 online resource (xxxix, 825 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier textual sapdv EBSCOhost Includes bibliographical references and index. 1. Reaction solvent selection2. Reagent selection3. Various reagent surrogates4. Modes of reagent addition -control of impurity formation5. Process optimization with additives6. Process optimization of catalytic reactions7. Process optimization of problematic reactions8. Hazards of oxidation and reduction reactions9. Other hazardous reactions10. Hazardous reagents11. Grignard reagent and related reactions12. Challenging reaction intermediates13. Protecting groups14. Telescope approach15. Design of new synthetic route16. Stereochemistry17. Various quenching strategies18. Various isolation and purification strategies19. Methods for residual metal removal20. Methods for impurity removal21. Pharmaceutical salts22. Solid form "This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies"-- Provided by publisher. EBSCOhost "EBSCO evaluates our products based on the Web Content Accessibility Guidelines (WCAG) and the related Section 508 and EN 301 549 regulations in the US and EU. Most EBSCO products are substantially conformant with WCAG 2.2 level AA." Source: https://connect.ebsco.com/s/article/EBSCO-VPATs?language=en_US. Last accessed April 22, 2025. Description based on online resource; title from digital title page (viewed on October 20, 2023). Drugs Research. 64804 Drugs Research Methodology. 64805 Pharmaceutical industry. 64806 Drug Industry 64807 SCIENCE / Chemistry / Industrial & Technical bisacsh 64808 TECHNOLOGY / Engineering / Chemical & Biochemical bisacsh 63924 MEDICAL / Pharmacology bisacsh 64250 has work: Handbook for chemical process research and development (Text) https://id.oclc.org/worldcat/entity/E39PCFvmYfJx7cXVTtwDJWmprm https://id.oclc.org/worldcat/ontology/hasWork Print version: Zhao, Wenyi Handbook for chemical process research and development Second edition. Boca Raton, FL : CRC Press, [2023] 9781032259277 (DLC) 2022047640 EBSCOhost https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3547971 Askews and Holts Library Services ASKH AH40838475 EBSCOhost EBSC 3547971 92 N$T 56069 56069