Zhao, Wenyi (Chemist) creator author. text bibliography flu 2023 2023 Second edition. monographic eng 1 online resource (xxxix, 825 pages) : illustrations "This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies"-- 1. Reaction solvent selection2. Reagent selection3. Various reagent surrogates4. Modes of reagent addition -control of impurity formation5. Process optimization with additives6. Process optimization of catalytic reactions7. Process optimization of problematic reactions8. Hazards of oxidation and reduction reactions9. Other hazardous reactions10. Hazardous reagents11. Grignard reagent and related reactions12. Challenging reaction intermediates13. Protecting groups14. Telescope approach15. Design of new synthetic route16. Stereochemistry17. Various quenching strategies18. Various isolation and purification strategies19. Methods for residual metal removal20. Methods for impurity removal21. Pharmaceutical salts22. Solid form authored by Wenyi Zhao, Senior Research Scientist, Jacobus Pharmaceutical Company, Princeton. Includes bibliographical references and index. Drugs Research Drugs Research Methodology Pharmaceutical industry Drug Industry SCIENCE / Chemistry / Industrial & Technical TECHNOLOGY / Engineering / Chemical & Biochemical MEDICAL / Pharmacology RM301.25 .Z44 2023 Zhao, Wenyi Boca Raton, FL : CRC Press, [2023] Second edition. (DLC) 2022047640 9781003288411 1003288413 9781000859010 1000859010 9781000859058 1000859053 2022047641 9781003288411 Taylor & Francis https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3547971 https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3547971 EBZ 221125 20251029164105.0 on1365767404 eng