05646nam a22005415i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001400172072001600186072002300202072001500225245012800240250001800368264007500386300006400461336002600525337002600551338003600577347002400613490007000637505239900707520132603106650002104432650001904453650003404472650001804506650002504524650002504549650002304574650003304597650002704630650002504657700008604682710003404768773002604802776003604828776003604864776003604900830007704936856004605013912001405059912001405073999001705087978-3-031-43883-7DE-He21320251030110846.0cr nn 008mamaa231201s2024    sz |    s    |||| 0|eng d  a97830314388379978-3-031-43883-77 a10.1007/978-3-031-43883-72doi 4aQH573-671 7aPSF2bicssc 7aSCI0170002bisacsh 7aPSF2thema10aImplication of Oxysterols and Phytosterols in Aging and Human Diseasesh[electronic resource] /cedited by Gérard Lizard.  a1st ed. 2024. 1aCham :bSpringer International Publishing :bImprint: Springer,c2024.  aXV, 462 p. 66 illus., 51 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aAdvances in Experimental Medicine and Biology,x2214-8019 ;v14400 aPart I. Chemical Characteristics -- Chapter 1. The Structure of Oxysterols Determines their Behavior at Phase Boundaries – Implications for Model Membranes and Structure-Activity Relationships -- Chapter 2. Association of ABCG5 and ABCG8 Transporters with Sitosterolemia -- Part II. Bio- and Chemical- Synthesis, and Analytical Methods -- Chapter 3. Chemical and Biochemical Features of Spinasterol and Schottenol -- Chapter 4. LC-MS Approaches for Oxysterols in Various Biosamples -- Chapter 5. Mass Spectrometry Imaging of Cholesterol and Oxysterols -- Part III. Implication in Aging and Human Diseases -- Chapter 6. Oxysterols in Central and Peripheral Synaptic Communication -- Chapter 7. Oxysterols in Infectious Diseases -- Chapter 8. The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases -- Chapter 9. Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects -- Chapter 10. Enzymatically Formed Oxysterols and Cell Death -- Chapter 11. Oxysterols in Vascular Cells and Role in Atherosclerosis -- Chapter 12. Implication of Oxysterols and Phytosterols in Aging and Human Diseases -- Chapter 13. Sterols in Inflammatory Diseases: Implications and Clinical Utility -- Chapter 14. Role of Oxysterols in Ocular Degeneration Mechanisms and Involvement of P2X7 Receptor -- Chapter 15. 24S-Hydroxycholesterol in Neuropsychiatric Diseases: Schizophrenia, Autism Spectrum Disorder and Bipolar Disorder -- Part IV. Biomarkers Therapeutic and Industrial Applications -- Chapter 16. Oxysterols as Biomarkers of Aging and Disease -- Chapter 17. The Diagnostic Use of the Plasma Quantification of 24S-Hydroxycholesterol and Other Oxysterols in Neurodegenerative Disease -- Chapter 18. Oxy- and Phytosterols as Biomarkers: Current Status and Future Perspectives -- Part V. Pharmacological Applications -- Chapter 19. Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancer -- Part VI. Industrial Aspects -- Chapter 20. Current and New Insights on Delivery Systems for Plant Sterols in Food -- Chapter 21. In vitro Evaluation of the Effects of 7-Ketocholesterol and 7β-Hydroxycholesterol on the Peroxisomal Status: Prevention of Peroxisomal Damages and Concept of Pexotherapy -- Chapter 22. Phytosterols: Potential Therapeutic Effects and Challenges in Food Industry.  aThis book provides basic knowledge of the biology, chemistry, and function of oxysterols and its derivatives as well as of phytosterols in numerous human diseases. The book is divided into six sections and begins with an introduction to the biological and chemical properties of oxysterols and its derivatives as well as phytosterols, their synthesis, and the methods currently used for their detection in various biospecimens. The following section discusses in detail the various effects of oxysterols on numerous human diseases, including infectious diseases, inflammatory and autoimmune diseases, atherosclerosis, and cancer, as well as neurological and neuropsychiatric disorders. Importantly, the potential of oxysterols as biomarkers for some of these diseases is also highlighted. The book concludes with an outlook on the pharmacological and nutritional effects of oxysterols and phytosterols and their potential use by the food, and pharmaceutical industries. Aiming to provide an in-depth overview of the biological and the chemical properties of oxysterols and phytosterols and their implications for human health, this book will be of interest to basic and clinical scientists, as well as to anyone working in the food or pharmaceutical industry who is exploring the potential of oxysterols and phytosterols. 0aCytology.967436 0aLipids.967824 0aClinical biochemistry.967825 0aCancer.94311 0aInflammation.96782614aCell Biology.96744024aLipidology.96782724aMedical Biochemistry.96782824aCancer Biology.96782924aInflammation.9678261 aLizard, Gérard.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9678302 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303143882008iPrinted edition:z978303143884408iPrinted edition:z9783031438851 0aAdvances in Experimental Medicine and Biology,x2214-8019 ;v144096783140uhttps://doi.org/10.1007/978-3-031-43883-7  aZDB-2-SBL  aZDB-2-SXB  c56711d56711