05010nam a22005535i 4500 978-3-031-42108-2 DE-He213 20251030110914.0 cr nn 008mamaa 240104s2024 sz | s |||| 0|eng d 9783031421082 978-3-031-42108-2 10.1007/978-3-031-42108-2 doi QR46 MMFM bicssc MED052000 bisacsh MKFM thema Updates on Clostridioides difficile in Europe [electronic resource] : Advances in Microbiology, Infectious Diseases and Public Health Volume 18 / edited by Paola Mastrantonio, Maja Rupnik. 2nd ed. 2024. Cham : Springer International Publishing : Imprint: Springer, 2024. X, 362 p. 28 illus., 25 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advances in Microbiology, Infectious Diseases and Public Health, 2365-2683 ; 1435 Economic burden of Clostridioides difficile infection in European countries -- The need for European surveillance of CDI.-Diagnostic guidance for C. difficile infections -- European practice for CDI treatment -- Faecal microbiota transplantation as emerging treatment in European countries 2.0 -- Probiotics for prevention and treatment of Clostridioides difficile infection -- Immunization strategies against Clostridioides difficile -- Ribotypes and new virulent strains across Europe -- Antibiotic resistances of Clostridioides difficile -- Comparative genomics of Clostridioides difficile -- An updated view on the cellular uptake and mode-of-action of Clostridioides difficile toxins -- Clostridioides difficile biofilm -- Clostridioides difficile sporulation -- Membrane vesicles of C.difficile and other Clostridial species -- Non-human C.difficile reservoirs and sources: animals,food, environment -- The ESCMID Study Group for Clostridioides difficile : history, role and perspectives. This fully updated second edition outlines the currently available clinical, epidemiological and experimental data on Clostridioides difficile infections(CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are taken into consideration for their relevance from epidemiological and evolutionary point of view. The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. New topics included sporulation and membrane vesicles in C. difficile. The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment. Medical microbiology. 63858 Diseases. 68840 Microbiology. Medical Microbiology. 63858 Diseases. 68840 Microbiology. Mastrantonio, Paola. editor. edt http://id.loc.gov/vocabulary/relators/edt 69209 Rupnik, Maja. editor. edt http://id.loc.gov/vocabulary/relators/edt 69210 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031421075 Printed edition: 9783031421099 Printed edition: 9783031421105 Advances in Microbiology, Infectious Diseases and Public Health, 2365-2683 ; 1435 69211 https://doi.org/10.1007/978-3-031-42108-2 ZDB-2-SBL ZDB-2-SXB 57085 57085