04788nam a22005055i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050000900172072001700181072002300198072001600221245019600237250001800433264007500451300006300526336002600589337002600615338003600641347002400677490008800701505099900789520182501788650003303613650002103646650001803667650003303685650002103718650001803739700008903757700008203846710003403928773002603962776003603988776003604024776003604060830009504096856004604191912001404237912001404251999001704265978-3-031-42108-2DE-He21320251030110914.0cr nn 008mamaa240104s2024    sz |    s    |||| 0|eng d  a97830314210829978-3-031-42108-27 a10.1007/978-3-031-42108-22doi 4aQR46 7aMMFM2bicssc 7aMED0520002bisacsh 7aMKFM2thema10aUpdates on Clostridioides difficile in Europeh[electronic resource] :bAdvances in Microbiology, Infectious Diseases and Public Health Volume 18 /cedited by Paola Mastrantonio, Maja Rupnik.  a2nd ed. 2024. 1aCham :bSpringer International Publishing :bImprint: Springer,c2024.  aX, 362 p. 28 illus., 25 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aAdvances in Microbiology, Infectious Diseases and Public Health,x2365-2683 ;v14350 aEconomic burden of Clostridioides difficile infection in European countries -- The need for European surveillance of CDI.-Diagnostic guidance for C. difficile infections -- European practice for CDI treatment -- Faecal microbiota transplantation as emerging treatment in European countries 2.0 -- Probiotics for prevention and treatment of Clostridioides difficile infection -- Immunization strategies against Clostridioides difficile -- Ribotypes and new virulent strains across Europe -- Antibiotic resistances of Clostridioides difficile -- Comparative genomics of Clostridioides difficile -- An updated view on the cellular uptake and mode-of-action of Clostridioides difficile toxins -- Clostridioides difficile biofilm -- Clostridioides difficile sporulation -- Membrane vesicles of C.difficile and other Clostridial species -- Non-human C.difficile reservoirs and sources: animals,food, environment -- The ESCMID Study Group for Clostridioides difficile : history, role and perspectives.  aThis fully updated second edition outlines the currently available clinical, epidemiological and experimental data on Clostridioides difficile infections(CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are taken into consideration for their relevance from epidemiological and evolutionary point of view. The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. New topics included sporulation and membrane vesicles in C. difficile. The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment. 0aMedical microbiology.963858 0aDiseases.968840 0aMicrobiology.14aMedical Microbiology.96385824aDiseases.96884024aMicrobiology.1 aMastrantonio, Paola.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9692091 aRupnik, Maja.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9692102 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303142107508iPrinted edition:z978303142109908iPrinted edition:z9783031421105 0aAdvances in Microbiology, Infectious Diseases and Public Health,x2365-2683 ;v143596921140uhttps://doi.org/10.1007/978-3-031-42108-2  aZDB-2-SBL  aZDB-2-SXB  c57085d57085