03443nam a22005295i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001000153072001700163072002300180072001600203245011200219250001800331264007500349300006600424336002600490337002600516338003600542347002400578490005600602505095800658520065101616650001802267650001202285650001902297650003402316650001602350650001902366650001802385650002002403650002802423650001602451650001902467700007702486700008002563710003402643773002602677776003602703776003602739776003602775830005602811856004602867978-3-031-42859-3DE-He21320251030110914.0cr nn 008mamaa240104s2024    sz |    s    |||| 0|eng d  a97830314285937 a10.1007/978-3-031-42859-32doi 4aRB131 7aMJCM2bicssc 7aMED0440002bisacsh 7aMJCM2thema10aMacrolides as Immunomodulatory Agentsh[electronic resource] /cedited by Bruce K. Rubin, Masaharu Shinkai.  a1st ed. 2024. 1aCham :bSpringer International Publishing :bImprint: Springer,c2024.  aVIII, 287 p. 18 illus., 10 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aProgress in Inflammation Research,x2296-4525 ;v920 aPart I. Mechanisms of Action and Novel Macrolides -- Macrolides and Diseases Associated with Loss of Epithelial Barrier Integrity -- Macrolides and Inflammatory Cells, Signaling, and Mediators -- Part II. Clinical Use for Airway Disease -- Macrolides as Immunomodulatory Agents -- Macrolides and Cystic Fibrosis -- Non-CF Bronchiectasis -- Macrolide Use in Chronic Obstructive Pulmonary Disease -- Macrolides and Asthma Therapy -- Macrolides and Interstitial Lung Diseases -- Macrolides in Acute Respiratory Distress Syndrome and Acute Lung Injury -- Azithromycin for Other Lung Diseases: Lung Transplantation and Sarcoidosis -- Macrolides for Rhinosinusitis and Nasal Polyps -- Part III. Clinical Use for Other Diseases -- Macrolides for Cancer -- Macrolides in Chronic Skin Disorders -- Macrolide Use in Preschool Aged Children with Acute or Recurrent Respiratory Tract Illnesses with Wheezing -- Macrolides and Immunomodulation: Today and the Future.  aFor over 50 years, clinicians have known that macrolide antibiotics have effects on inflammation and the immune system that are not related to their antimicrobial properties. These immunomodulatory properties, best described for treating inflammatory airway diseases, protect the lung and the host and improve clinical status. This book summarizes our current knowledge regarding proposed mechanisms for these properties, established clinical results, and what the future may hold with emphasis on novel clinical applications and the fascinating development of non-antimicrobial macrolides with preserved and enhanced immunomodulatory properties. 0aInflammation. 0aCancer. 0aImmune system. 0aCellular signal transduction. 0aImmunology. 0aImmunotherapy.14aInflammation.24aCancer Biology.24aImmune Cell Signalling.24aImmunology.24aImmunotherapy.1 aRubin, Bruce K.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt1 aShinkai, Masaharu.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303142858608iPrinted edition:z978303142860908iPrinted edition:z9783031428616 0aProgress in Inflammation Research,x2296-4525 ;v9240uhttps://doi.org/10.1007/978-3-031-42859-3