03889nam a22006255i 4500 978-3-031-42859-3 DE-He213 20251030110914.0 cr nn 008mamaa 240104s2024 sz | s |||| 0|eng d 9783031428593 978-3-031-42859-3 10.1007/978-3-031-42859-3 doi RB131 MJCM bicssc MED044000 bisacsh MJCM thema Macrolides as Immunomodulatory Agents [electronic resource] / edited by Bruce K. Rubin, Masaharu Shinkai. 1st ed. 2024. Cham : Springer International Publishing : Imprint: Springer, 2024. VIII, 287 p. 18 illus., 10 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Progress in Inflammation Research, 2296-4525 ; 92 Part I. Mechanisms of Action and Novel Macrolides -- Macrolides and Diseases Associated with Loss of Epithelial Barrier Integrity -- Macrolides and Inflammatory Cells, Signaling, and Mediators -- Part II. Clinical Use for Airway Disease -- Macrolides as Immunomodulatory Agents -- Macrolides and Cystic Fibrosis -- Non-CF Bronchiectasis -- Macrolide Use in Chronic Obstructive Pulmonary Disease -- Macrolides and Asthma Therapy -- Macrolides and Interstitial Lung Diseases -- Macrolides in Acute Respiratory Distress Syndrome and Acute Lung Injury -- Azithromycin for Other Lung Diseases: Lung Transplantation and Sarcoidosis -- Macrolides for Rhinosinusitis and Nasal Polyps -- Part III. Clinical Use for Other Diseases -- Macrolides for Cancer -- Macrolides in Chronic Skin Disorders -- Macrolide Use in Preschool Aged Children with Acute or Recurrent Respiratory Tract Illnesses with Wheezing -- Macrolides and Immunomodulation: Today and the Future. For over 50 years, clinicians have known that macrolide antibiotics have effects on inflammation and the immune system that are not related to their antimicrobial properties. These immunomodulatory properties, best described for treating inflammatory airway diseases, protect the lung and the host and improve clinical status. This book summarizes our current knowledge regarding proposed mechanisms for these properties, established clinical results, and what the future may hold with emphasis on novel clinical applications and the fascinating development of non-antimicrobial macrolides with preserved and enhanced immunomodulatory properties. Inflammation. 67826 Cancer. 4311 Immune system. 69212 Cellular signal transduction. 69213 Immunology. 69214 Immunotherapy. 69215 Inflammation. 67826 Cancer Biology. 67829 Immune Cell Signalling. 69216 Immunology. 69214 Immunotherapy. 69215 Rubin, Bruce K. editor. edt http://id.loc.gov/vocabulary/relators/edt 69217 Shinkai, Masaharu. editor. edt http://id.loc.gov/vocabulary/relators/edt 69218 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031428586 Printed edition: 9783031428609 Printed edition: 9783031428616 Progress in Inflammation Research, 2296-4525 ; 92 69219 https://doi.org/10.1007/978-3-031-42859-3 ZDB-2-SBL ZDB-2-SXB 57086 57086