03478nam a22005175i 4500 978-3-031-51346-6 DE-He213 20251030110914.0 cr nn 008mamaa 240104s2024 sz | s |||| 0|eng d 9783031513466 978-3-031-51346-6 10.1007/978-3-031-51346-6 doi RM300-666 MMG bicssc MED071000 bisacsh MKG thema Anion Channels and Transporters [electronic resource] / edited by Christoph Fahlke. 1st ed. 2024. Cham : Springer International Publishing : Imprint: Springer, 2024. X, 362 p. 100 illus., 30 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Handbook of Experimental Pharmacology, 1865-0325 ; 283 Preface -- Muscle chloride channels -- Adrenal anion channels - new roles in zona glomerulosa physiology and in the pathophysiology of primary aldosteronism -- ClC-K Kidney Chloride Channels : from structure to pathology -- Biophysical and pharmacological insights to CLC chloride channels and Transporters -- Function and regulation of the calcium-activated chloride channel anoctamin 1 -- Structure and function of calcium-activated chloride channels and scramblases in TMEM16 family -- Structural basis for anion-selective Cys-loop receptor signal transduction and modulation -- Physiological functions of the volume regulated anion channel VRAC/LRRC8 and the proton-activated chloride channel PAC/TMEM206 -- CFTR modulators: from mechanism to targeted therapeutics -- Structure, physiology, and pharmacology of chloride-dependent cation cotransporters -- SLC26 Anion Transporters -- Pharmacology of Na-dependent transporters of inorganic phosphate -- Simulation of fluoride anions in CLC proteins: from potent inhibition to selective transport. This book provides an overview on recent progress in anion channels and transporters. It covers multiple scales of analysis ranging from studying the molecular basis of function at atomic resolution to cellular consequences to channel/transporter dysfunction and approaches to correct such processes by pharmacological intervention. Similar anion channels and transporters are expressed in multiple tissues – often fulfilling similar cellular tasks, but also clearly distinct functions. The aim is to combine work on multiple cell and organ systems. Pharmacology. 67844 Human physiology. 69239 Pharmacology. 67844 Human Physiology. 69240 Fahlke, Christoph. editor. edt http://id.loc.gov/vocabulary/relators/edt 69241 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031513459 Printed edition: 9783031513473 Printed edition: 9783031513480 Handbook of Experimental Pharmacology, 1865-0325 ; 283 69242 https://doi.org/10.1007/978-3-031-51346-6 ZDB-2-SBL ZDB-2-SXB 57095 57095