03261nam a22004695i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001400172072001600186072002300202072001500225245009000240250001800330264007500348300006400423336002600487337002600513338003600539347002400575490006100599505105300660520055601713650002502269650002902294650002502323650002902348700008702377710003402464773002602498776003602524776003602560776003602596830006802632856004602700912001402746912001402760999001702774978-3-031-51346-6DE-He21320251030110914.0cr nn 008mamaa240104s2024    sz |    s    |||| 0|eng d  a97830315134669978-3-031-51346-67 a10.1007/978-3-031-51346-62doi 4aRM300-666 7aMMG2bicssc 7aMED0710002bisacsh 7aMKG2thema10aAnion Channels and Transportersh[electronic resource] /cedited by Christoph Fahlke.  a1st ed. 2024. 1aCham :bSpringer International Publishing :bImprint: Springer,c2024.  aX, 362 p. 100 illus., 30 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aHandbook of Experimental Pharmacology,x1865-0325 ;v2830 aPreface -- Muscle chloride channels -- Adrenal anion channels - new roles in zona glomerulosa physiology and in the pathophysiology of primary aldosteronism -- ClC-K Kidney Chloride Channels : from structure to pathology -- Biophysical and pharmacological insights to CLC chloride channels and Transporters -- Function and regulation of the calcium-activated chloride channel anoctamin 1 -- Structure and function of calcium-activated chloride channels and scramblases in TMEM16 family -- Structural basis for anion-selective Cys-loop receptor signal transduction and modulation -- Physiological functions of the volume regulated anion channel VRAC/LRRC8 and the proton-activated chloride channel PAC/TMEM206 -- CFTR modulators: from mechanism to targeted therapeutics -- Structure, physiology, and pharmacology of chloride-dependent cation cotransporters -- SLC26 Anion Transporters -- Pharmacology of Na-dependent transporters of inorganic phosphate -- Simulation of fluoride anions in CLC proteins: from potent inhibition to selective transport.  aThis book provides an overview on recent progress in anion channels and transporters. It covers multiple scales of analysis ranging from studying the molecular basis of function at atomic resolution to cellular consequences to channel/transporter dysfunction and approaches to correct such processes by pharmacological intervention. Similar anion channels and transporters are expressed in multiple tissues – often fulfilling similar cellular tasks, but also clearly distinct functions. The aim is to combine work on multiple cell and organ systems. 0aPharmacology.967844 0aHuman physiology.96923914aPharmacology.96784424aHuman Physiology.9692401 aFahlke, Christoph.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9692412 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303151345908iPrinted edition:z978303151347308iPrinted edition:z9783031513480 0aHandbook of Experimental Pharmacology,x1865-0325 ;v28396924240uhttps://doi.org/10.1007/978-3-031-51346-6  aZDB-2-SBL  aZDB-2-SXB  c57095d57095