04988nam a22006375i 4500 978-3-031-30023-3 DE-He213 20251030111405.0 cr nn 008mamaa 240129s2024 sz | s |||| 0|eng d 9783031300233 978-3-031-30023-3 10.1007/978-3-031-30023-3 doi RS400-431 PSB bicssc SCI013040 bisacsh PNB thema Pharmaceutical Biotechnology [electronic resource] : Fundamentals and Applications / edited by Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm. 6th ed. 2024. Cham : Springer International Publishing : Imprint: Springer, 2024. XXV, 682 p. 259 illus., 245 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Molecular Biotechnology -- Biophysical and biochemical analysis of recombinant proteins -- Production and downstream processing of biotech products -- Formulation of biotech products, including biopharmaceutical considerations -- Pharmacokinetics and pharmacodynamics of peptide and protein drugs -- Immunogenicity of pharmaceutical proteins -- General considerations of monoclonal antibodies from structure to therapeutic application -- Genomics, Other “Omics” Technologies, Personalized Medicine and Additional Biotechnology-Related Techniques -- Dispensing biotechnology products: handling, professional education and product information -- Economic considerations in medical biotechnology -- Regulatory framework for biosimilars -- Vaccines -- Oligonucleotides and siRNA -- Gene therapy -- Stem cell technology -- Therapeutic Applications.-Endocrinology -- Insulin -- Follicle-stimulating hormone -- Growth hormone -- Cardiovascular and Respiratory Applications -- Recombinant coagulation factors and thrombolytics -- Recombinant human deoxyribonuclease -- Oncology -- Monoclonal antibodies in oncology -- Hematopoetic growth factors -- Inflammation and Immunemodulation -- Monoclonal antibodies in transplantation -- Monoclonal antibodies and antibody-based therapeutics in anti-inflammatory therapy -- Interferons and interleukins -- Anti-infectious diseases -- Monoclonal antibodies -- Enzyme replacement therapy. This introductory text explains both the basic science, production, quality, dosage forms, administration, economic and regulatory aspects and the clinical applications of biotechnology-derived pharmaceuticals. It serves as a complete one-stop source for undergraduate/graduate pharmacists and pharmaceutical science students. An additional important audience are pharmaceutical scientists in industry and academia, particularly those who have not received formal training in pharmaceutical biotechnology and are inexperienced in this field. The rapid growth and advances in the field made it necessary to revise this textbook in order to continue providing up-to-date information and introduce readers to cutting edge knowledge and technology of this field. This Sixth Edition completely updates the previous edition and includes additional coverage on new approaches such as oligonucleotides, siRNA, mRNA, gene therapy, cell therapies, monoclonal antibodies and vaccines. With more than 3-million-chapter downloads, the fifth edition of the textbook has achieved widespread distribution as a key educational resource for the field of pharmaceutical biotechnology. Pharmaceutical chemistry. 67843 Biotechnology. 65162 Pharmacology. 67844 Medicine Research. 62598 Biology Research. 65629 Drug delivery systems. Biologicals. 70032 Biopharmaceutics. 70033 Pharmaceutics. 67846 Biotechnology. 65162 Pharmacology. 67844 Biomedical Research. 65633 Drug Delivery. 69429 Biologics. 70034 Crommelin, Daan J. A. editor. edt http://id.loc.gov/vocabulary/relators/edt 70035 Sindelar, Robert D. editor. edt http://id.loc.gov/vocabulary/relators/edt 70036 Meibohm, Bernd. editor. edt http://id.loc.gov/vocabulary/relators/edt 70037 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031300226 Printed edition: 9783031300240 Printed edition: 9783031303272 https://doi.org/10.1007/978-3-031-30023-3 ZDB-2-SBL ZDB-2-SXB 57340 57340