03025nam a22005055i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001900153050001400172072001600186072002300202072001600225100007400241245011600315250001800431264007200449300006800521336002600589337002600615338003600641347002400677490007200701505037000773520088901143650001802032650001902050650002802069650002002097650003102117650001802148650002802166650002002194650001902214710003402233773002602267776003602293776003602329776003602365830007202401856004602473978-981-99-9400-7DE-He21320251030111415.0cr nn 008mamaa240203s2024    si |    s    |||| 0|eng d  a97898199940077 a10.1007/978-981-99-9400-72doi 4aTA418.95-455.2 4aQP620-625 7aTGM2bicssc 7aTEC0210002bisacsh 7aTGML2thema1 aMori, Keita.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut10aMetal-Responsive Base Pair Switching of Ligand-type Uracil Nucleobasesh[electronic resource] /cby Keita Mori.  a1st ed. 2024. 1aSingapore :bSpringer Nature Singapore :bImprint: Springer,c2024.  aXVII, 125 p. 111 illus., 101 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aSpringer Theses, Recognizing Outstanding Ph.D. Research,x2190-50610 a1. General introduction -- 2. Metal-responsive DNA strand displacement reactions driven by base pair switching of 5-hydroxyuracil nucleobases -- 3. Metal-dependent base pair switching of N,N,-dicarboxymethyl-5-aminouracil nucleosides -- 4. Metal-responsive DNA tweezers driven by base pair switching of 5-hydroxyuracil nucleobases -- 5. Conclusion and perspectives.  aIn this thesis, the author proposes "metal-responsive base pair switching" of ligand-modified nucleobases as a novel tool for stimuli-responsive control of DNA assemblies. It is written to demonstrate broad applicability of the base pair switching in dynamic DNA nanotechnology and inspire researchers to use this technique. Based on specific interactions between ligand-type nucleobases and target metal ions, in this volume, DNA hybridization was dynamically controlled through strand displacement reactions. The base pair switching was further applied to develop metal-dependent DNA molecular machines. This novel strategy for stimuli-responsive regulation of DNA assemblies will greatly expand the scope of dynamic DNA nanotechnology. This volume uniquely features importance of elaborate molecular design based on chemistry for imparting stimuli responsiveness to DNA assemblies. 0aBiomaterials. 0aNucleic acids. 0aCoordination compounds. 0aNanotechnology. 0aSelf-assembly (Chemistry).14aNucleic Acid.24aCoordination Chemistry.24aNanotechnology.24aSelf-assembly.2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978981999399408iPrinted edition:z978981999401408iPrinted edition:z9789819994021 0aSpringer Theses, Recognizing Outstanding Ph.D. Research,x2190-506140uhttps://doi.org/10.1007/978-981-99-9400-7