03432nam a22006015i 4500 978-981-99-9400-7 DE-He213 20251030111415.0 cr nn 008mamaa 240203s2024 si | s |||| 0|eng d 9789819994007 978-981-99-9400-7 10.1007/978-981-99-9400-7 doi TA418.95-455.2 QP620-625 TGM bicssc TEC021000 bisacsh TGML thema Mori, Keita. author. aut http://id.loc.gov/vocabulary/relators/aut 70553 Metal-Responsive Base Pair Switching of Ligand-type Uracil Nucleobases [electronic resource] / by Keita Mori. 1st ed. 2024. Singapore : Springer Nature Singapore : Imprint: Springer, 2024. XVII, 125 p. 111 illus., 101 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5061 1. General introduction -- 2. Metal-responsive DNA strand displacement reactions driven by base pair switching of 5-hydroxyuracil nucleobases -- 3. Metal-dependent base pair switching of N,N,-dicarboxymethyl-5-aminouracil nucleosides -- 4. Metal-responsive DNA tweezers driven by base pair switching of 5-hydroxyuracil nucleobases -- 5. Conclusion and perspectives. In this thesis, the author proposes "metal-responsive base pair switching" of ligand-modified nucleobases as a novel tool for stimuli-responsive control of DNA assemblies. It is written to demonstrate broad applicability of the base pair switching in dynamic DNA nanotechnology and inspire researchers to use this technique. Based on specific interactions between ligand-type nucleobases and target metal ions, in this volume, DNA hybridization was dynamically controlled through strand displacement reactions. The base pair switching was further applied to develop metal-dependent DNA molecular machines. This novel strategy for stimuli-responsive regulation of DNA assemblies will greatly expand the scope of dynamic DNA nanotechnology. This volume uniquely features importance of elaborate molecular design based on chemistry for imparting stimuli responsiveness to DNA assemblies. Biomaterials. Nucleic acids. 70554 Coordination compounds. 70555 Nanotechnology. Self-assembly (Chemistry). 70556 Nucleic Acid. 70557 Coordination Chemistry. 70558 Nanotechnology. Self-assembly. 70559 SpringerLink (Online service) Springer Nature eBook Printed edition: 9789819993994 Printed edition: 9789819994014 Printed edition: 9789819994021 Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5061 66370 https://doi.org/10.1007/978-981-99-9400-7 ZDB-2-CMS ZDB-2-SXC 57474 57474