TY  - BOOK
AU  - Mori,Keita
ED  - SpringerLink (Online service)
TI  - Metal-Responsive Base Pair Switching of Ligand-type Uracil Nucleobases
T2  - Springer Theses, Recognizing Outstanding Ph.D. Research,
SN  - 9789819994007
AV  - TA418.95-455.2 
PY  - 2024///
CY  - Singapore
PB  - Springer Nature Singapore, Imprint: Springer
KW  - Biomaterials
KW  - Nucleic acids
KW  - Coordination compounds
KW  - Nanotechnology
KW  - Self-assembly (Chemistry)
KW  - Nucleic Acid
KW  - Coordination Chemistry
KW  - Self-assembly
N1  - 1. General introduction -- 2. Metal-responsive DNA strand displacement reactions driven by base pair switching of 5-hydroxyuracil nucleobases -- 3. Metal-dependent base pair switching of N,N,-dicarboxymethyl-5-aminouracil nucleosides -- 4. Metal-responsive DNA tweezers driven by base pair switching of 5-hydroxyuracil nucleobases -- 5. Conclusion and perspectives
N2  - In this thesis, the author proposes "metal-responsive base pair switching" of ligand-modified nucleobases as a novel tool for stimuli-responsive control of DNA assemblies. It is written to demonstrate broad applicability of the base pair switching in dynamic DNA nanotechnology and inspire researchers to use this technique. Based on specific interactions between ligand-type nucleobases and target metal ions, in this volume, DNA hybridization was dynamically controlled through strand displacement reactions. The base pair switching was further applied to develop metal-dependent DNA molecular machines. This novel strategy for stimuli-responsive regulation of DNA assemblies will greatly expand the scope of dynamic DNA nanotechnology. This volume uniquely features importance of elaborate molecular design based on chemistry for imparting stimuli responsiveness to DNA assemblies
UR  - https://doi.org/10.1007/978-981-99-9400-7
ER  -