Mitaku, Shigeki. creator author. aut http://id.loc.gov/vocabulary/relators/aut Sawada, Ryusuke. author. aut http://id.loc.gov/vocabulary/relators/aut SpringerLink (Online service) text si 2024 1st ed. 2024. monographic eng

electronic

electronic resource

access X, 144 p. 83 illus., 51 illus. in color. online resource. This book aims to understand biological evolution through a physical approach, focusing on the macroscopic aspects of the biological genome. Readers will discover the connection between genomic information and the harmony of biological systems, a relationship that remains elusive to many researchers in biological sciences. The most common approach to understanding living organisms with physics is to begin with a single molecule of an organism. In contrast to this bottom-up approach, building from each molecule to the whole, this book takes a coarse-grained approach at the amino acid level to physically understand the macroscopic aspects of the organism. The book presents a system developed by the authors to predict membrane proteins with high accuracy using only physical parameters. Another distinctive perspective of this book is that it proposes the idea of a physical mechanism, other than natural selection, that orchestrates the emergence of order from random processes. Thestudy of macroscopic aspects of living organisms based on this concept has parallels with thermostatistical mechanics for states of matter. Just as random processes create order in matter, there are physical random processes that form order in living organisms. This analogy is the central theme of the book. Using terms and analogies familiar to physicists, the book bridges the gap between biological and physical sciences. The book focuses on simple principles and is aimed primarily at researchers. While the content of this book is at the boundary area of biophysics, soft matter physics and bioinformatics, it will also be of interest to researchers and graduate students working on any biological topics. The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Chapter 1. Organisms viewed from real space and sequence space -- Chapter 2. The relationship between biology and physics -- Chapter 3. Three-dimensional structures of proteins responsible for biological functions -- Chapter 4. Molecular devices that support genome processing -- Chapter 5. Biological membranes and membrane proteins -- Chapter 6. Signal transduction and enzymatic metabolic reactions in living organisms -- Chapter 7. System biology and protein structure prediction by computer -- Chapter 8. Similarities in order formation in matter and organisms -- Chapter 9. Protein distribution analysis by a high-precision prediction system for membrane proteins -- Chapter 10. : Changes in the proportion of membrane proteins by mutation simulation -- Chapter 11. Habitable zone in nucleotide composition space: Phase diagram of life -- Chapter 12. Relationship between the phase diagram of life and protein distribution -- Chapter 13. Definition of species and mysteries of evolution -- Chapter 14.Biological hierarchies and various mutations in genome sequences -- Chapter 15. Analysis of viruses, and the fusion of biology and physics through the phase diagram of life. by Shigeki Mitaku, Ryusuke Sawada. Evolution (Biology) Biophysics Bioinformatics Evolutionary Biology Biophysics Bioinformatics QH359-425 9789819700608 https://doi.org/10.1007/978-981-97-0060-8 https://doi.org/10.1007/978-981-97-0060-8 240220 20251030111435.0 978-981-97-0060-8