05582nam a22006255i 4500 978-3-031-49744-5 DE-He213 20251030111438.0 cr nn 008mamaa 240222s2024 sz | s |||| 0|eng d 9783031497445 978-3-031-49744-5 10.1007/978-3-031-49744-5 doi QP361-430 QP90.2 PSAN bicssc SCI089000 bisacsh PSAN thema Regenerative Medicine and Brain Repair [electronic resource] / edited by Philip V. Peplow, Bridget Martinez, Thomas A. Gennarelli. 1st ed. 2024. Cham : Springer International Publishing : Imprint: Springer, 2024. XIV, 343 p. 29 illus., 28 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Stem Cell Biology and Regenerative Medicine, 2196-8993 ; 75 Initiating and Facilitating Brain Repair: Factors, Principles, and Mechanisms -- Strategies to Upgrade the Stem Cell Application for Brain Transplantation -- Neural Stem Cell Intervention in Traumatic Brain Injury -- Neurotrophic Factors in Parkinson’s Disease: Clinical Trials -- Emerging Nanotechnology for the Treatment and Diagnosis of Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) -- Poly(Butyl Cyanoacrylate) Nanoparticles deliver β-Nerve Growth Factor to the Brain after Traumatic Brain Injury -- The Significance of Biomaterials in Stem Cell-Based Regenerative Medicine -- Endogenous in situ Tissue Regeneration using Inductive Bioscaffolds after Acute Brain Injury -- Alginate Nanofibre Scaffolds for Amyotrophic Lateral Sclerosis -- Developing High-Fidelity in vitro Models of Traumatic Brain Injury to Test Therapeutic Biomaterials -- Challenges and Future Perspectives of Using Bioactive Scaffolds in Brain Repair. This book presents the latest knowledge, trends, and advances in cell transplantation and innovations in developing microspheres, 3D biomaterial constructs to enhance transfer, and cell survival to specific regions of the brain. Neurodegenerative diseases and brain injury are increasing. Medications currently only temporarily reduce some of the symptoms but do not cure or delay progression of the disease. Development of effective treatments dramatically improves the independent living and quality of life of patients. Cell transplantation strategies offer an approach to facilitating brain repair, but efficacy is often limited by low in vivo survival rates of cells that are injected in suspension. Transplanting cells that are attached to or encapsulated within a biomaterial construct has the advantage of maintaining cell-cell and cell-material interactions and improving cell survival in vivo. Biomaterials that have been used in preclinical studies to assist with in vivo cell transfer and survival include heparin-chitosan microspheres, poly(lactic-co-glycolic acid) microspheres, RADA 16 microspheres, poly(desaminotyrosyl tyrosine ethyl ester carbonate) microscale scaffolds, carbon nanotubes, collagen-chitosan scaffolds, poly(L-lactic acid) scaffolds, agarose hydrogels, gelatin methacrylate hydrogels, and agarose micro-columns with an extracellular matrix interior. Incorporating growth factors (e.g., glial-derived neurotrophic factor, neurotrophin 3) into the biomaterial constructs increased cell survival and incorporation into the host tissue. International experts in the fields of both experimental and clinical neurological research contribute chapters to this book and discuss the latest achievements in cell transplantation and matrix-assisted cell transfer/survival technologies for diseases such as Alzheimer’s disease, Parkinson’s disease, and brain injuries such as stroke and traumatic brain injury. It is envisaged that research findings in experimental animal models of Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, and stroke promote clinical trials using biomaterial-assisted transfer of cells. Nervous system Regeneration. 71547 Regenerative medicine. 67458 Stem cells. 67435 Biomedical engineering. Biomaterials. Regeneration and Repair in the Nervous System. 71548 Regenerative Medicine and Tissue Engineering. 67459 Stem Cell Biology. 67439 Biomedical Engineering and Bioengineering. Biomaterials. Peplow, Philip V. editor. edt http://id.loc.gov/vocabulary/relators/edt 71549 Martinez, Bridget. editor. edt http://id.loc.gov/vocabulary/relators/edt 71550 Gennarelli, Thomas A. editor. edt http://id.loc.gov/vocabulary/relators/edt 71551 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031497438 Printed edition: 9783031497452 Printed edition: 9783031497469 Stem Cell Biology and Regenerative Medicine, 2196-8993 ; 75 71552 https://doi.org/10.1007/978-3-031-49744-5 ZDB-2-SBL ZDB-2-SXB 57803 57803