04445nam a22006255i 4500 978-3-031-42422-9 DE-He213 20251030111502.0 cr nn 008mamaa 240210s2024 sz | s |||| 0|eng d 9783031424229 978-3-031-42422-9 10.1007/978-3-031-42422-9 doi QD241-441 PNN bicssc SCI013040 bisacsh PNN thema Neurotrophic Natural Products [electronic resource] / edited by A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. IX, 473 p. 297 illus., 54 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Progress in the Chemistry of Organic Natural Products, 2192-4309 ; 123 1. Neurotrophins and Screening Models to Search for Neurotrophic Natural Products -- 2. Fatty Acid-Related Compounds with Neurotrophic Activity -- 3. Terpenes Possessing Neurotrophic Activity -- 4. Aromatic Compounds Possessing Neurotrophic Activity -- 5. Alkaloids Possessing Neurotrophic Properties -- 6. Closing Remarks. This book deals with neurotrophins (NGF, BDNF, NT3, NT4), which can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons. This makes neurotrophins potential therapeutic agents for the treatment of neurodegenerative disorders. However, these proteins have so far been ineffective in clinical trials mostly because they cannot pass the blood-brain barrier owing to their high-molecular weights. Consequently, small molecules that mimic neurotrophins and stimulate the synthesis of endogenous neurotrophins or enhance their neurotrophic actions are expected to be promising alternatives. Small-molecule natural products, which have been used in dietary functional foods or in traditional medicine over the course of human history, have potential to be developed as new therapeutic agents against neurodegenerative conditions such as Alzheimer’s disease. In this book, the authors introduce a variety of natural products possessing neurotrophic properties such as neurogenesis, neurite outgrowth promotion (neuritogenesis), and neuroprotection and focus on the chemistry and biology of several neurotrophic natural products. Natural products. Chemistry. Neurochemistry. 72462 Chemistry, Organic. 65325 Natural Products. Chemical Synthesis. 68822 Neurochemistry. 72462 Organic Chemistry. 65327 Kinghorn, A. Douglas. editor. (orcid)0000-0002-6647-8707 https://orcid.org/0000-0002-6647-8707 edt http://id.loc.gov/vocabulary/relators/edt 72463 Falk, Heinz. editor. edt http://id.loc.gov/vocabulary/relators/edt 72464 Gibbons, Simon. editor. (orcid)0000-0003-1587-6809 https://orcid.org/0000-0003-1587-6809 edt http://id.loc.gov/vocabulary/relators/edt 72465 Asakawa, Yoshinori. editor. (orcid)0000-0002-1847-412X https://orcid.org/0000-0002-1847-412X edt http://id.loc.gov/vocabulary/relators/edt 72466 Liu, Ji-Kai. editor. (orcid)0000-0001-6279-7893 https://orcid.org/0000-0001-6279-7893 edt http://id.loc.gov/vocabulary/relators/edt 72467 Dirsch, Verena M. editor. (orcid)0000-0002-9261-5293 https://orcid.org/0000-0002-9261-5293 edt http://id.loc.gov/vocabulary/relators/edt 72468 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031424212 Printed edition: 9783031424236 Printed edition: 9783031424243 Progress in the Chemistry of Organic Natural Products, 2192-4309 ; 123 72469 https://doi.org/10.1007/978-3-031-42422-9 ZDB-2-CMS ZDB-2-SXC 58123 58123