04183nam a22004815i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001400153072001600167072002300183072001500206245017300221250001800394264007200412300004300484336002600527337002600553338003600579347002400615505125800639520111501897650001803012650001903030650002403049650002303073650001803096650001903114650002503133700009203158700008003250700007803330700007903408710003403487773002603521776003603547776003603583776003603619856004603655978-981-99-9183-9DE-He21320251030111726.0cr nn 008mamaa240318s2024    si |    s    |||| 0|eng d  a97898199918397 a10.1007/978-981-99-9183-92doi 4aRM300-666 7aMMG2bicssc 7aMED0710002bisacsh 7aMKG2thema10aDrugs from Nature: Targets, Assay Systems and Leadsh[electronic resource] /cedited by Madhathilkovilakathu Haridas, Sabu Abdulhameed, Dileep Francis, Swaroop S Kumar.  a1st ed. 2024. 1aSingapore :bSpringer Nature Singapore :bImprint: Springer,c2024.  aXIV, 568 p. 1 illus.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aChapter 1. History of therapeutic discovery from natural sources -- Chapter 2. The process of drug development from natural sources -- Chapter 3. Ayurveda-inspired reverse pharmacology in drug discovery -- Chapter 4. Contemporary approaches in drug target identification and validation -- Chapter 5. Assay systems for identification of drug leads: contemporary approaches -- Chapter 6. Computational biology in lead identification and drug development -- Chapter 7. Physiology of inflammatory responses to external and autoimmune agents of diseases -- Chapter 8. Non-steroidal anti-inflammatory drug leads from natural sources -- Chapter 9. Mechanisms of side effects of non-steroidal anti-inflammatory drugs -- Chapter 10. Therapeutic targets in cancer -- Chapter 11. Anti-neoplastic drug leads from plants and microbes -- Chapter 12. Anti-fungal, anti-bacterial, and anti-parasitic therapeutics from natural sources -- Chapter 13. Anti-viral therapeutics from plants and microbes -- Chapter 14. Cardiovascular therapeutics from natural sources -- Chapter 15. Antidiabetics and antilipemics from nature -- Chapter 16. Therapeutic targets and drug leads for reproductive health -- Chapter 17. Drug leadsfor neuro-muscular disorders from natural sources.  aThis book provides an overview of the drug discovery process from natural sources such as plants and microbes. While technological advances have streamlined the drug discovery process, enhancing the throughput and success rates, the structural features of natural products remain the primary reference for small-molecule drug discovery. Focusing on the drug targets blocked/altered by natural/nature-inspired molecules, it covers how potential drug leads are screened and identified using appropriate assay systems, and the current status of drugs identified using such approaches. State-of-the-art approaches in target identification, assay development, and lead identification have also been discussed in detail. Other topics included are targets and leads in inflammation, cancer, reproductive medicine, cardiovascular and neuromuscular ailments, and infectious diseases as well as the challenges in translating drug leads into clinically viable drugs. This volume serves as a handbook for researchers in phytochemistry and drug discovery, and as a reference for researchers and students of applied biology. 0aPharmacology. 0aBiotechnology. 0aMedicinexResearch. 0aBiologyxResearch.14aPharmacology.24aBiotechnology.24aBiomedical Research.1 aHaridas, Madhathilkovilakathu.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt1 aAbdulhameed, Sabu.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt1 aFrancis, Dileep.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt1 aKumar, Swaroop S.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978981999182208iPrinted edition:z978981999184608iPrinted edition:z978981999185340uhttps://doi.org/10.1007/978-981-99-9183-9