03251nam a22004815i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001600172072001600188072002300204072001500227245008900242250001800331264007500349300006500424336002600489337002600515338003600541347002400577505041800601520117101019650002402190650002302214650002902237650002202266650002302288650002902311700008402340700008602424710003402510773002602544776003602570776003602606776003602642856004602678912001402724912001402738999001702752978-3-031-41777-1DE-He21320251030111810.0cr nn 008mamaa240409s2024    sz |    s    |||| 0|eng d  a97830314177719978-3-031-41777-17 a10.1007/978-3-031-41777-12doi 4aRC346-429.2 7aMJN2bicssc 7aMED0560002bisacsh 7aMKJ2thema10aStroke Geneticsh[electronic resource] /cedited by Pankaj Sharma, James F. Meschia.  a3rd ed. 2024. 1aCham :bSpringer International Publishing :bImprint: Springer,c2024.  aXII, 624 p. 50 illus., 32 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aIntroduction -- Familial stroke epidemiology -- Association study results -- GWAS -- Aneurysms/carvernous/AVM -- ICH/amyloid/microbleeds -- CADASIL -- Fabry -- MELAS -- Sickle -- Other monogenic -- White matter disease -- Carotid atherosclerosis -- Dissection -- Pharmacogenomics -- Non-Caucasian stroke genetics -- Small vessel disease -- Genetics of neuroimaging in stroke -- Cerebrovenous thrombosis -- Ethics.  aThis revised, expanded third edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics. Each chapter now contains teaching/training MCQs to help with retention of information learnt from each chapter and this will be of considerable use to those training or about to the examined in the field of inherited stroke. Additional questions via app: Download the Springer Nature Flashcards app for free and use exclusive additional material to test your knowledge. 0aNeurology .966816 0aInternal medicine. 0aMedical genetics.96497614aNeurology.96681624aInternal Medicine.24aMedical Genetics.9649761 aSharma, Pankaj.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9748761 aMeschia, James F.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9748772 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303141776408iPrinted edition:z978303141778808iPrinted edition:z978303141779540uhttps://doi.org/10.1007/978-3-031-41777-1  aZDB-2-SME  aZDB-2-SXM  c59014d59014