03886nam a22005655i 4500 978-3-031-55287-8 DE-He213 20251030111817.0 cr nn 008mamaa 240413s2024 sz | s |||| 0|eng d 9783031552878 978-3-031-55287-8 10.1007/978-3-031-55287-8 doi QP34-38 MFG bicssc SCI036000 bisacsh MFG thema Chen, Chang-Hwei. author. aut http://id.loc.gov/vocabulary/relators/aut 75136 Activation and Detoxification Enzymes [electronic resource] : Functions and Implications / by Chang-Hwei Chen. 2nd ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. XXI, 251 p. 50 illus. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Overview -- Foreign Compounds: Foods, Drugs, Chemicals and Life Styles -- Transport and Excretion of Foreign Compounds -- Metabolic Conversion of Foreign Compounds -- Phase I Activation Enzymes -- Phase II Detoxification Enzymes -- Catalytic Reactions of Activation Enzymes -- Catalytic Reactions of Detoxification Enzymes -- Reactive Intermediates and their Interactions -- Metabolite - Associated Cell Toxicities -- Oxidative Stress and Electrophilic Stress -- Metabolic Enzymes: Polymorphism and Species Differences -- Defense Against Oxidative Stress: Nrf2-ARE Pathway -- Inducibility of Metabolic Enzymes -- Inducers of Metabolic Enzymes -- Diversified Classes of Enzyme Modulators -- Metabolite - Mediated Disease Conditions -- Metabolic Enzyme Induction for Health Benefits -- Diet Effects on Metabolic Enzymes. This book discusses the many advances in the understanding of the functions and implications of activation and detoxification enzymes. This organized, concise overview will meet the needs of those who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology, and chemistry. The book will also be valuable to advanced researchers. The book discusses subjects associated with foreign-compound-metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, activation and detoxification enzymes, metabolic enzyme catalytic properties, reactive metabolic intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary-related enzyme modulators, and structural characteristics of enzyme inducers. This new edition is updated throughout and features completely new chapters on Oxidative and Electrophilic Stresses, Metabolite- Mediated Disease Conditions, and Defense Mechanism: Nrf2-ARE Pathway. . Human physiology. Enzymology. 73630 Pharmacology. 67844 Nutrition   . 68694 Bioinformatics. 64050 Human Physiology. Enzymology. 73630 Pharmacology. 67844 Nutrition. 68694 Computational and Systems Biology. 65974 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031552861 Printed edition: 9783031552885 Printed edition: 9783031552892 https://doi.org/10.1007/978-3-031-55287-8 ZDB-2-SBL ZDB-2-SXB 59112 59112