03669nam a22005175i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001200172072001600184072002300200072001500223100008600238245011800324250001800442264006900460300004400529336002600573337002600599338003600625347002400661505082300685520112101508650002202629650002302651650002502674650002802699650002702727650002202754650002302776650002502799650002202824650004602846710003402892773002602926776003602952776003602988776003603024856004603060912001403106912001403120999001703134978-3-031-55287-8DE-He21320251030111817.0cr nn 008mamaa240413s2024    sz |    s    |||| 0|eng d  a97830315528789978-3-031-55287-87 a10.1007/978-3-031-55287-82doi 4aQP34-38 7aMFG2bicssc 7aSCI0360002bisacsh 7aMFG2thema1 aChen, Chang-Hwei.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut97513610aActivation and Detoxification Enzymesh[electronic resource] :bFunctions and Implications /cby Chang-Hwei Chen.  a2nd ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aXXI, 251 p. 50 illus.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aOverview -- Foreign Compounds: Foods, Drugs, Chemicals and Life Styles -- Transport and Excretion of Foreign Compounds -- Metabolic Conversion of Foreign Compounds -- Phase I Activation Enzymes -- Phase II Detoxification Enzymes -- Catalytic Reactions of Activation Enzymes -- Catalytic Reactions of Detoxification Enzymes -- Reactive Intermediates and their Interactions -- Metabolite - Associated Cell Toxicities -- Oxidative Stress and Electrophilic Stress -- Metabolic Enzymes: Polymorphism and Species Differences -- Defense Against Oxidative Stress: Nrf2-ARE Pathway -- Inducibility of Metabolic Enzymes -- Inducers of Metabolic Enzymes -- Diversified Classes of Enzyme Modulators -- Metabolite - Mediated Disease Conditions -- Metabolic Enzyme Induction for Health Benefits -- Diet Effects on Metabolic Enzymes.  aThis book discusses the many advances in the understanding of the functions and implications of activation and detoxification enzymes. This organized, concise overview will meet the needs of those who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology, and chemistry. The book will also be valuable to advanced researchers. The book discusses subjects associated with foreign-compound-metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, activation and detoxification enzymes, metabolic enzyme catalytic properties, reactive metabolic intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary-related enzyme modulators, and structural characteristics of enzyme inducers. This new edition is updated throughout and features completely new chapters on Oxidative and Electrophilic Stresses, Metabolite- Mediated Disease Conditions, and Defense Mechanism: Nrf2-ARE Pathway. . 0aHuman physiology. 0aEnzymology.973630 0aPharmacology.967844 0aNutrition   .968694 0aBioinformatics.96405014aHuman Physiology.24aEnzymology.97363024aPharmacology.96784424aNutrition.96869424aComputational and Systems Biology.9659742 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303155286108iPrinted edition:z978303155288508iPrinted edition:z978303155289240uhttps://doi.org/10.1007/978-3-031-55287-8  aZDB-2-SBL  aZDB-2-SXB  c59112d59112