03294nam a22005295i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001600172072001600188072002300204072001500227100008600242245016800328250001800496264008200514300004400596336002600640337002600666338003600692347002400728490003600752505037000788520109401158650002402252650002302276650002202299650002702321650002802348650002202376650002302398650002202421650002702443650002802470710003402498773002602532776003602558776003602594830004302630856004602673912001402719912001402733999001702747978-3-662-68840-3DE-He21320251030112014.0cr nn 008mamaa240426s2024    gw |    s    |||| 0|eng d  a97836626884039978-3-662-68840-37 a10.1007/978-3-662-68840-32doi 4aRC346-429.2 7aMJN2bicssc 7aMED0560002bisacsh 7aMKJ2thema1 aReiber, Hansotto.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut97584910aCerebrospinal Fluid Diagnostics in Neurologyh[electronic resource] :bParadigm Change in Brain Barriers, Immune System and Chronic Diseases /cby Hansotto Reiber.  a1st ed. 2024. 1aBerlin, Heidelberg :bSpringer Berlin Heidelberg :bImprint: Springer,c2024.  aXVII, 73 p. 16 illus.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aSpringer essentials,x2731-31150 aThe cerebrospinal fluid - the CSF -- Barrier functions -- CSF diagnostics -- Knowledge base immune reactions in the brain -- Knowledge base chronic diseases -- Knowledge base complex systems -- Knowledge base: biological stability and material self-organization -- Diagnostics of disease as an emergent whole -- Paradigm shift - a scientific-theoretical commentary.  aThis Springer essential explains the theoretical foundations for knowledge-based interpretation of medical laboratory data. Self-organization of biological structure, non-linear dynamics of complex systems and immunological network theories make it possible to describe pathomechanisms and diagnostics, especially of chronic diseases, as an expression of a phenotypic biology and to develop concepts for causal therapies. The book shows how CSF diagnostics with a diagnostic report integrating all laboratory data can identify disease-typical patterns for the differential diagnosis of bacterial, viral, parasitic, oncological, chronic inflammatory, autoimmunological and psychiatric diseases. A CSF app is provided as a tutorial program. The author Prof. Dr. Hansotto Reiber, University of Göttingen, is retired Professor of Neurochemistry. His current work describes biophysical principles in biology and medicine with a focus on complexity sciences. The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content. 0aNeurology .966816 0aPsychiatry.970761 0aPathology.974914 0aNeurochemistry.972462 0aNeuroimmunology.97585014aNeurology.96681624aPsychiatry.97076124aPathology.97491424aNeurochemistry.97246224aNeuroimmunology.9758502 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978366268839708iPrinted edition:z9783662688410 0aSpringer essentials,x2731-311597376640uhttps://doi.org/10.1007/978-3-662-68840-3  aZDB-2-SME  aZDB-2-SXM  c59427d59427