03163nam a22004335i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001400153072001700167072002300184072001600207245012500223250001800348264007200366300006600438336002600504337002600530338003600556347002400592505071000616520092901326650001202255650002302267650002002290650002902310650002002339700008102359700007502440710003402515773002602549776003602575776003602611776003602647856004602683978-981-97-1666-1DE-He21320251030112030.0cr nn 008mamaa240506s2024    si |    s    |||| 0|eng d  a97898197166617 a10.1007/978-981-97-1666-12doi 4aRC261-271 7aMJCL2bicssc 7aMED0620002bisacsh 7aMJCL2thema10aDrug Resistance in Cancer: Mechanisms and Strategiesh[electronic resource] /cedited by Sameer Ullah Khan, Fayaz Malik.  a1st ed. 2024. 1aSingapore :bSpringer Nature Singapore :bImprint: Springer,c2024.  aXXIX, 372 p. 58 illus., 56 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 a1. Introduction to Drug Resistance in Cancer -- 2. Mechanisms of Cancer Resistance to Various Therapies -- 3. Role of cancer Stem Cells in Drug Resistance -- 4. Immune cells - Critical players in Drug Resistance -- 5. Tumor Microenvironment: Multiway Role in Drug Resistance -- 6. Cancer Drug Resistance and Metabolic Reprogramming -- 7. Epigenetic alterations as an adaptive response to chemotherapy -- 8. Autophagy plays a dual role in drug resistance -- 9. Intracellular compartments and drug resistance -- 10. Gut microbes: Role in cancer and cancer drug resistance -- 11. Novel strategies for overcoming drug resistance -- 12. Future directions and challenges in overcoming drug resistance in cancer.  aThis book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing Combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options. 0aCancer. 0aCancerxTreatment.14aCancer Biology.24aCancer Microenvironment.24aCancer Therapy.1 aKhan, Sameer Ullah.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt1 aMalik, Fayaz.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978981971665408iPrinted edition:z978981971667808iPrinted edition:z978981971668540uhttps://doi.org/10.1007/978-981-97-1666-1