03560nam a22005295i 4500 978-981-97-1666-1 DE-He213 20251030112030.0 cr nn 008mamaa 240506s2024 si | s |||| 0|eng d 9789819716661 978-981-97-1666-1 10.1007/978-981-97-1666-1 doi RC261-271 MJCL bicssc MED062000 bisacsh MJCL thema Drug Resistance in Cancer: Mechanisms and Strategies [electronic resource] / edited by Sameer Ullah Khan, Fayaz Malik. 1st ed. 2024. Singapore : Springer Nature Singapore : Imprint: Springer, 2024. XXIX, 372 p. 58 illus., 56 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda 1. Introduction to Drug Resistance in Cancer -- 2. Mechanisms of Cancer Resistance to Various Therapies -- 3. Role of cancer Stem Cells in Drug Resistance -- 4. Immune cells - Critical players in Drug Resistance -- 5. Tumor Microenvironment: Multiway Role in Drug Resistance -- 6. Cancer Drug Resistance and Metabolic Reprogramming -- 7. Epigenetic alterations as an adaptive response to chemotherapy -- 8. Autophagy plays a dual role in drug resistance -- 9. Intracellular compartments and drug resistance -- 10. Gut microbes: Role in cancer and cancer drug resistance -- 11. Novel strategies for overcoming drug resistance -- 12. Future directions and challenges in overcoming drug resistance in cancer. This book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing Combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options. Cancer. 4311 Cancer Treatment. 63722 Cancer Biology. 67829 Cancer Microenvironment. 75774 Cancer Therapy. 73414 Khan, Sameer Ullah. editor. edt http://id.loc.gov/vocabulary/relators/edt 76458 Malik, Fayaz. editor. edt http://id.loc.gov/vocabulary/relators/edt 76459 SpringerLink (Online service) Springer Nature eBook Printed edition: 9789819716654 Printed edition: 9789819716678 Printed edition: 9789819716685 https://doi.org/10.1007/978-981-97-1666-1 ZDB-2-SBL ZDB-2-SXB 59684 59684