04045nam a22005535i 4500 978-3-031-51292-6 DE-He213 20251030112050.0 cr nn 008mamaa 240521s2024 sz | s |||| 0|eng d 9783031512926 978-3-031-51292-6 10.1007/978-3-031-51292-6 doi RC254-282 MJCL bicssc MED062000 bisacsh MJCL thema Neuroblastoma [electronic resource] : Discoveries and Challenges / edited by Shahab Asgharzadeh, Frank Westermann. 1st ed. 2024. Cham : Springer International Publishing : Imprint: Springer, 2024. X, 219 p. 21 illus., 20 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Pediatric Oncology, 2191-0812 Epidemiology, Presentation, and Evaluation -- Pathology of Neuroblastoma -- Genetic Predisposition -- Part I: Evolving Concepts in Neuroblastoma Pathogenesis (Seed):Tumor Genomics: Copy Number Alterations -- Tumor Genomics: Epigenetics -- Tumor Genomics: Genomic Regulation -- Tumor Metabolism -- Part II: Evolving Concepts in Neuroblastoma Immunology and Tumor Microenvironment (Soil): Neuroblastoma Tumor Microenvironment - Adaptive and Innate Immunity -- Neuroblastoma Tumor Microenvironment – Non-Immune Cells and Exosomes -- Part III: Evolving Concepts in Neuroblastoma Precision Medicine: Targeting the Seed and the Soil: Advances in evaluating tumor burden -- Therapeutically Actionable Genetic Aberrations -- Re-engaging the Immune System: Future of Immunotherapy -- Future of Clinical Trials and Application of Precision Medicine -- Summary and the Next 10 Years. . This book provides a state-of-the-art review of the biology, treatment, and other critical aspects of neuroblastoma, reflecting the dramatic advances that have been achieved in understanding and management. Topics are arranged according to the book’s dominant themes of the “seed” (tumor genomics, epigenetics, metabolism, and stem cells) and the “soil” (tumor microenvironment, adaptive and innate immunity, and exosomes) and how both of these influences can serve as rich targets for intervention, whether by targeted molecular therapy or immunotherapy. Therapeutic strategies that are currently in use or under consideration for the future are discussed in detail, with the focus on precision medicine. Further individual chapters are devoted to the biology and genetics of relapsed/refractory neuroblastoma and emerging methods of evaluating tumor burden. Finally, in keeping with the, albeit modest, increase in cure rates in high-risk disease, immune and cellular therapies are reviewed. This coverage of what is becoming a not-so-enigmatic tumor will appeal to a broad readership including both experimental oncologists and clinicians who care for patients with neuroblastoma. Oncology. 70760 Pediatrics. 64087 Neurology . 66816 Oncology. 70760 Pediatrics. 64087 Neurology. 66816 Asgharzadeh, Shahab. editor. edt http://id.loc.gov/vocabulary/relators/edt 77123 Westermann, Frank. editor. edt http://id.loc.gov/vocabulary/relators/edt 77124 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031512919 Printed edition: 9783031512933 Printed edition: 9783031512940 Pediatric Oncology, 2191-0812 77125 https://doi.org/10.1007/978-3-031-51292-6 ZDB-2-SME ZDB-2-SXM 59990 59990