03885nam a22005535i 4500 978-3-031-59028-3 DE-He213 20251030112243.0 cr nn 008mamaa 240530s2024 sz | s |||| 0|eng d 9783031590283 978-3-031-59028-3 10.1007/978-3-031-59028-3 doi QH324.2-324.25 PS bicssc UY bicssc SCI008000 bisacsh PSAX thema Borges Coutinho Gallo, Margareth. author. aut http://id.loc.gov/vocabulary/relators/aut 77833 Seeking Molecular Biomarkers for Schizophrenia Using ROC Analysis [electronic resource] / by Margareth Borges Coutinho Gallo. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. XV, 250 p. 96 illus., 95 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Preface -- Hypotheses of the Pathophysiology of Schizophrenia Spectrum Disorders -- Biomarkers -- Biomarkers Related to the Hypotheses of the Pathophysiology of SSD -- Immunoinflammatory and Oxidative-Stress Related Biomarkers -- Gut Microbiota-Brain Axis and Related Biomarkers -- Neuroendocrine Biomarkers -- Neurotrophic Biomarkers -- Neurotransmitter Biomarkers -- Conclusions -- Step-by-Step Guide to Building a Diagnostic Model Using MetaboAnalyst -- Index. Schizophrenia Spectrum Disorders (SSD) manifest multidimensionally, presenting a syndromic nature with several symptomatic domains. These are driven by dynamic systemic biological changes that unfold over the course of the disease. Thus far, the diagnosis is solely based on symptoms, which may be rather subjective, moving research toward the search for SSD biomarkers. This book presents a summary of the main hypotheses that have evolved over time to explain the pathophysiology of SSD and that have driven the discovery of associated biomarkers: neurotrophic, neurotransmitter, neuroendocrine, immune-inflammatory, nitrosative/oxidative stress, metabolic, and gut microbiota-brain axis. The book shows the most relevant research carried out in the last twelve years to develop predictive, diagnostic, theranostic or transdiagnostic models based on these biomarkers using the receiver operating characteristic curve (ROC) analysis. Chapters also discuss how the literature has addressed the development and/or addition of new discriminatory biomarkers to achieve robust and successful results. The book is rounded out with a step-by-step explanation on how to work on the MetaboAnalyst platform, including the meaning of the chosen statistics and how to interpret them in the results obtained. This book is a useful resource for students and scientists involved in the discovery of biomarkers for psychiatric disorders and other diseases. Bioinformatics. 64050 Medicine Research. 62598 Biology Research. 65629 Psychiatry. 70761 Computational and Systems Biology. 65974 Biomedical Research. 65633 Psychiatry. 70761 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031590276 Printed edition: 9783031590290 Printed edition: 9783031595851 https://doi.org/10.1007/978-3-031-59028-3 ZDB-2-SBL ZDB-2-SXB 60291 60291