03256nam a22004815i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001400153072001600167072002300183072001500206245013200221250001800353264007200371300006300443336002600506337002600532338003600558347002400594490005200618505009700670520147000767650002402237650002502261650002602286650002402312650002302336650002502359650002602384650002402410700007402434710003402508773002602542776003602568776003602604776003602640830005202676856004602728978-981-19-9585-9DE-He21320251030112243.0cr nn 008mamaa240530s2024    si |    s    |||| 0|eng d  a97898119958597 a10.1007/978-981-19-9585-92doi 4aQD241-441 7aPNN2bicssc 7aSCI0130402bisacsh 7aPNN2thema10aInvestigations on Signal Transduction Processes Utilizing Small Chemical Probesh[electronic resource] /cedited by Lihe Zhang.  a1st ed. 2024. 1aSingapore :bSpringer Nature Singapore :bImprint: Springer,c2024.  aXIX, 57 p. 12 illus., 6 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aReports of China’s Basic Research,x2731-89150 aProject Overview -- Domestic and Foreign Research -- Major Research Achievements -- Outlook.  aThis book presents a major research program investigating signal transduction processes utilizing small molecule compound probes. The program was launched by the National Natural Science Foundation of China during the 11th Five-Year Plan period, which was started in October 2008 and concluded at the end of 2016. It first summarizes the overall scientific objectives and the current situation of signal transduction research in China and the international frontier. Based on the new method and technologies achieved in small molecule compound probes, this book illustrates key molecular events in signal transduction processes in living systems and reveals the regulation of signal transduction. This helps to explore new ideas and strategies for the diagnosis and prevention of serious diseases. In addition, via interdisciplinary cooperation of biology and chemistry, this book solves some key scientific problems in biology and promotes recent developments in these fields. These areas include the generation of small molecule compound probes for studying signal transduction and development of detecting methods for gathering information of biomacromolecule activities. Given its scope, the book is of interest to researchers who work in organic chemistry, natural product chemistry, medicinal chemistry, analytical chemistry and physical chemistry. It also promotes the multidisciplinary collaboration among chemistry, medicine, materials science and biology. 0aChemistry, Organic. 0aMedicinal chemistry. 0aAnalytical chemistry. 0aPhysical chemistry.14aOrganic Chemistry.24aMedicinal Chemistry.24aAnalytical Chemistry.24aPhysical Chemistry.1 aZhang, Lihe.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978981199584208iPrinted edition:z978981199586608iPrinted edition:z9789819900336 0aReports of China’s Basic Research,x2731-891540uhttps://doi.org/10.1007/978-981-19-9585-9