04850nam a22005415i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001700172072001600189072002300205072001500228100008500243245009000328250001800418264007500436300006300511336002600574337002600600338003600626347002400662505065400686520231401340650002603654650002703680650002703707650002303734650003903757650002803796650003603824650002703860650004603887650003303933650003603966650004704002710003404049773002604083776003604109776003604145776003604181856004604217912001404263912001404277999001704291978-3-031-42022-1DE-He21320251030112255.0cr nn 008mamaa240603s2024    sz |    s    |||| 0|eng d  a97830314202219978-3-031-42022-17 a10.1007/978-3-031-42022-12doi 4aTP248.13-.65 7aTCB2bicssc 7aTEC0090102bisacsh 7aTCB2thema1 aDi Paola, Luisa.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut97814610aFundamentals of Molecular Bioengineeringh[electronic resource] /cby Luisa Di Paola.  a1st ed. 2024. 1aCham :bSpringer International Publishing :bImprint: Springer,c2024.  aX, 271 p. 75 illus., 63 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aPart 1: Biomolecular Thermodynamics -- Chapter 1: Classical and Chemical Thermodynamics -- Chapter 2: Statistical hermodynamics -- chapter 3: Proteins -- Chapter 4: Intermolecular forces and potentials -- Chapter 5: Volumetric properties of fluids: equations of state -- Chapter 6: Biopolymers ionization and salting-out -- Chapter 7: Protein-ligand interactions and binding -- Part 2: Computational Biology -- Chapter 8: Molecular dynamics simulations for computational biology -- Chapter 9: Protein structure prediction and analysis -- Chapter 10: Systems biology and structure- based protein networks -- Chapter 11: Computational protein binding.  aThis textbook covers the scientific basics of molecular bioengineering, a new field where technology meets biology and chemistry, and the fundamental knowledge required for students to understand molecular mechanisms beyond biological phenomena. The textbook focuses on the role of proteins in biomolecular machinery, and it is divided into 2 parts: Part I covers the molecular thermodynamics of biological systems, and Part II discusses the computational aspects behind protein structure prediction and molecular dynamics. In the first part of the textbook, students will find comprehensive explanations of thermodynamics and statistical mechanics, which are the basis to understand how molecular properties translate into macroscopic. Part I also offers an introduction to proteins and concepts like intermolecular forces, volumetric properties of fluids, ionization equilibria and salting-out, and protein binding and protein-protein interactions. In the second part of the textbook, students will learn about protein structure prediction and analysis, systems biology and structure-based protein networks, and computational tools and approaches for molecular dynamics simulations and protein binding and protein-protein interactions. This textbook adds to the scholarly debate with a unique contribution, addressing important new areas of biophysical chemistry and molecular biophysics not covered in currently available textbooks. Given its breadth, the textbook is suitable for courses in molecular biophysics, biochemistry, physical chemistry and bioengineering, and will also appeal to researchers and professionals in these fields. Part I of this book is a translation from its Italian original manuscript done with the help of artificial intelligence. A subsequent human revision of the content was done by the author. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. This book is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. 0aBiotechnology.965162 0aThermodynamics.966400 0aBioinformatics.964050 0aProteins .970651 0aChemistryxData processing.969913 0aBiomedical engineering.14aChemical Bioengineering.96776124aThermodynamics.96640024aComputational and Systems Biology.96597424aProtein Biochemistry.97176824aComputational Chemistry.96991524aBiomedical Engineering and Bioengineering.2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303142021408iPrinted edition:z978303142023808iPrinted edition:z978303142024540uhttps://doi.org/10.1007/978-3-031-42022-1  aZDB-2-CMS  aZDB-2-SXC  c60467d60467