03956nam a22006015i 4500 978-3-031-44087-8 DE-He213 20251030112315.0 cr nn 008mamaa 240617s2024 sz | s |||| 0|eng d 9783031440878 978-3-031-44087-8 10.1007/978-3-031-44087-8 doi RB155-155.8 MFN bicssc MED107000 bisacsh MFN thema Congenital Heart Diseases: The Broken Heart [electronic resource] : Clinical Features, Human Genetics and Molecular Pathways / edited by Silke Rickert-Sperling, Robert G. Kelly, Nikolaus Haas. 2nd ed. 2024. Cham : Springer International Publishing : Imprint: Springer, 2024. XXXIV, 1112 p. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advances in Experimental Medicine and Biology, 2214-8019 ; 1441 Section I: General introduction in cardiac development -- Section II: Different chapters covering the different types of congenital heart disease -- Section III: The overall perspective. This 2nd edition has been extensively updated and provides comprehensive and current insight into congenital heart diseases, from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. The book is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and insights from animal models and pathways. All chapters have been updated and new chapters added on state-of-the-art approaches including stem cells and organoids, cardiac metabolism, single cell transcriptomics and 3D reconstruction of human heart development. The clinical chapters have been extended and include new sections on diagnostic imaging techniques. Taken together, the book, written by and for clinicians and researchers, provides an integrated and up-to-date resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease. Chapter 11 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. Medical genetics. 64976 Medicine Research. 62598 Biology Research. 65629 Cardiology. 75410 Medicine. 63923 Medical Genetics. 64976 Biomedical Research. 65633 Cardiology. 75410 Clinical Medicine. Rickert-Sperling, Silke. editor. edt http://id.loc.gov/vocabulary/relators/edt 78766 Kelly, Robert G. editor. edt http://id.loc.gov/vocabulary/relators/edt 78767 Haas, Nikolaus. editor. edt http://id.loc.gov/vocabulary/relators/edt 78768 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031440861 Printed edition: 9783031440885 Printed edition: 9783031440892 Advances in Experimental Medicine and Biology, 2214-8019 ; 1441 67831 https://doi.org/10.1007/978-3-031-44087-8 ZDB-2-SBL ZDB-2-SXB 60767 60767