03735nam a22005535i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001600172072001600188072002300204072001500227245020000242250001800442264007500460300003700535336002600572337002600598338003600624347002400660490007000684505019100754520139700945650002902342650003102371650003002402650002302432650002102455650002902476650003202505650002302537650002302560700009302583700008502676700008402761710003402845773002602879776003602905776003602941776003602977830007703013856004603090912001403136912001403150999001703164978-3-031-44087-8DE-He21320251030112315.0cr nn 008mamaa240617s2024    sz |    s    |||| 0|eng d  a97830314408789978-3-031-44087-87 a10.1007/978-3-031-44087-82doi 4aRB155-155.8 7aMFN2bicssc 7aMED1070002bisacsh 7aMFN2thema10aCongenital Heart Diseases: The Broken Hearth[electronic resource] :bClinical Features, Human Genetics and Molecular Pathways /cedited by Silke Rickert-Sperling, Robert G. Kelly, Nikolaus Haas.  a2nd ed. 2024. 1aCham :bSpringer International Publishing :bImprint: Springer,c2024.  aXXXIV, 1112 p.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aAdvances in Experimental Medicine and Biology,x2214-8019 ;v14410 aSection I: General introduction in cardiac development -- Section II: Different chapters covering the different types of congenital heart disease -- Section III: The overall perspective.  aThis 2nd edition has been extensively updated and provides comprehensive and current insight into congenital heart diseases, from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. The book is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and insights from animal models and pathways. All chapters have been updated and new chapters added on state-of-the-art approaches including stem cells and organoids, cardiac metabolism, single cell transcriptomics and 3D reconstruction of human heart development. The clinical chapters have been extended and include new sections on diagnostic imaging techniques. Taken together, the book, written by and for clinicians and researchers, provides an integrated and up-to-date resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease. Chapter 11 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. 0aMedical genetics.964976 0aMedicinexResearch.962598 0aBiologyxResearch.965629 0aCardiology.975410 0aMedicine.96392314aMedical Genetics.96497624aBiomedical Research.96563324aCardiology.97541024aClinical Medicine.1 aRickert-Sperling, Silke.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9787661 aKelly, Robert G.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9787671 aHaas, Nikolaus.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9787682 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303144086108iPrinted edition:z978303144088508iPrinted edition:z9783031440892 0aAdvances in Experimental Medicine and Biology,x2214-8019 ;v144196783140uhttps://doi.org/10.1007/978-3-031-44087-8  aZDB-2-SBL  aZDB-2-SXB  c60767d60767