04118nam a22005415i 4500 978-981-19-4484-0 DE-He213 20251030112318.0 cr nn 008mamaa 240618s2024 si | s |||| 0|eng d 9789811944840 978-981-19-4484-0 10.1007/978-981-19-4484-0 doi QR251-255 PSGH bicssc SCI045000 bisacsh PSG thema Tarique, Mohammed. author. aut http://id.loc.gov/vocabulary/relators/aut 78870 Drug Targets for Plasmodium Falciparum: Historic to Future Perspectives [electronic resource] / by Mohammed Tarique. 1st ed. 2024. Singapore : Springer Nature Singapore : Imprint: Springer, 2024. XIII, 199 p. 56 illus., 48 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Chapter 1. Introduction: An overview of Malaria and Plasmodium -- Chapter 2. Pathogenesis of Plasmodium falciparum -- Chapter 3. Antimalarial Drugs and drug resistance -- Chapter 4. Metabolic pathways of Enzymes: Therapeutic targets and prospects for Innovative antimalarial drugs -- Chapter 5. Targeting apicoplasts in Plasmodium falciparum, origin and pathways -- Chapter 6. Proteases and protein kinases as potential drug target -- Chapter 7. Plasmodium falciparum: Transporter and Drug Target -- Chapter 8. Enzymes of isoprenoid biosynthesis and control of malarial parasite plasmodium falciparum -- Chapter 9.Ubiquitin-Proteasome system as a potential drug target for Malaria -- Chapter 10.Food Vacuole as a Drug Target. This book offers a comprehensive exploration of malaria, a life-threatening disease affecting millions globally, with a focus on the parasitic organisms of the genus Plasmodium that cause it. It discusses the challenges posed by the disease, especially in economically developing regions, and delves into the biology and pathophysiology of the Plasmodium species, including their genetic flexibility and resistance to treatments. Special attention is given to P. falciparum, the most dangerous of these parasites, detailing its complex life cycle, interaction with human hosts, and the severe clinical manifestations it can induce. The book further explores the global health concern of antimalarial drug resistance, highlighting the WHO's efforts in combating the disease and the necessity for novel treatments. Innovative research directions, such as targeting the unique organelles of Plasmodium like the apicoplast and employing proteasome inhibitors, are thoroughly examined as potential strategies in the development of new antimalarial drugs. Additionally, it addresses the critical role of the hemoglobin digestion process in the parasite's lifecycle, presenting it as a promising target for therapeutic intervention. This work is an essential resource for researchers, clinicians, and policymakers involved in malaria control and drug development, providing insights into the current challenges and future directions in the fight against this endemic disease. Parasitology. 74758 Proteins. 70651 Diseases Causes and theories of causation. 78871 Pharmacology. 67844 Parasitology. 74758 Proteins. 70651 Pathogenesis. 78872 Pharmacology. 67844 SpringerLink (Online service) Springer Nature eBook Printed edition: 9789811944833 Printed edition: 9789811944857 Printed edition: 9789811944864 https://doi.org/10.1007/978-981-19-4484-0 ZDB-2-SBL ZDB-2-SXB 60811 60811