03511nam a22005415i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001400172072001600186072002300202072001500225100008300240245013100323250001800454264007200472300006400544336002600608337002600634338003600660347002400696490006900720505028100789520116701070650002502237650002302262650002102285650003802306650003502344650002502379650002302404650002502427650005202452700008902504700007702593710003402670773002602704776003602730776003602766830007602802856004602878912001402924912001402938999001702952978-981-97-1651-7DE-He21320251030112318.0cr nn 008mamaa240618s2024    si |    s    |||| 0|eng d  a97898197165179978-981-97-1651-77 a10.1007/978-981-97-1651-72doi 4aQD415-436 7aPSB2bicssc 7aSCI0070002bisacsh 7aPSB2thema1 aAgarwal, Ritu.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut97887810aModeling Calcium Signalingh[electronic resource] :bA Fractional Perspective /cby Ritu Agarwal, Sunil Dutt Purohit, Kritika.  a1st ed. 2024. 1aSingapore :bSpringer Nature Singapore :bImprint: Springer,c2024.  aXII, 76 p. 25 illus., 23 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aSpringerBriefs in Biochemistry and Molecular Biology,x2211-93610 aChapter 1 Introduction to Fractional Calculus and Modeling -- Chapter 2 Cytosolic Calcium Distribution and Thrombin Receptor Activation -- Chapter 3 Effects of Buffers over the Cytosolic Calcium Concentration -- Chapter 4 Anomalous Subdiffusive Behaviour of Cytosolic Calcium.  aThis book focuses on the fundamental processes involved in calcium signaling through fractional mathematical modeling. The intended reader of the book is mathematically proficient students of cell biology, applied mathematics and mathematical biology who are interested in learning about modeling in cell biology. The book inspires the graduate students and researchers to collaborate with experimentalists while studying the direction needed to explore the modeling literature. Organized into four chapters, the book introduces fractional calculus and is devoted to understanding the receptor activation by the ligand, that is Thrombin via fractional model incorporating the Caputo-Fabrizio fractional operator. It studies the calcium profile in red blood cells with the help of the advection-diffusion equation. The book further studies the process of buffering, aiding the lowering of the calcium concentration in the cytosol, which rises due to calcium influx from extracellular space and intracellular storage. It explains the concept of anomalous diffusion—a mathematical model is proposed to characterize the anomalous subdiffusion of cytosolic calcium. 0aBiochemistry.965465 0aMolecular biology. 0aCytology.967436 0aMathematical optimization.965522 0aCalculus of variations.96726814aBiochemistry.96546524aMolecular Biology.24aCell Biology.96744024aCalculus of Variations and Optimization.9672701 aPurohit, Sunil Dutt.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut9788791 aKritika.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut9788802 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978981971650008iPrinted edition:z9789819716524 0aSpringerBriefs in Biochemistry and Molecular Biology,x2211-936197888140uhttps://doi.org/10.1007/978-981-97-1651-7  aZDB-2-CMS  aZDB-2-SXC  c60814d60814