03817nam a22005895i 4500 978-981-97-1991-4 DE-He213 20251030112610.0 cr nn 008mamaa 240702s2024 si | s |||| 0|eng d 9789819719914 978-981-97-1991-4 10.1007/978-981-97-1991-4 doi QD241-441 PNN bicssc SCI013040 bisacsh PNN thema Seo, Tamae. author. aut http://id.loc.gov/vocabulary/relators/aut 79911 Palladium-Catalyzed Mechanochemical Cross-Coupling Reactions [electronic resource] / by Tamae Seo. 1st ed. 2024. Singapore : Springer Nature Singapore : Imprint: Springer, 2024. X, 278 p. 383 illus., 321 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5061 1. General Introduction -- 2. Olefin Accelerated Solid State C N Cross Coupling Using Mechanochemistry -- 3. Solid State Suzuki-Miyaura Cross Coupling Reactions Using Mechanochemistry -- 4. Tackling Solubility Issues in Organic Synthesis: Solid State Cross Coupling of Insoluble Aryl Halides -- 5. Solid State Cross Coupling Reactions of Insoluble Aryl Halides Under Polymer Assisted Grinding Conditions -- 6. Mechanochemistry Directed Ligand Design: Development of a High Performance Phosphine Ligand for Palladium Catalyzed Suzuki Miyaura Cross Coupling Reactions -- 7. Mechanochemical Monoarylation of Dihaloarenes Enabled by In Situ Crystallization -- 8. Metallamechanoredox: Force induced Nickel Catalyzed Arylamination Using Ball Milling and Piezoelectric Materials. In this thesis, the author developed cross-coupling reactions that proceed in the solid state without using organic solvents, utilizing a mechanochemical synthesis method using a ball mill. Compared to conventional solution systems, the reactions realized a drastic reduction of chemical waste, a drastic acceleration of chemical reactions, and efficient transformations of insoluble compounds. The thesis demonstrates that mechanochemical synthesis method has the potential to revolutionize organic synthesis. Readers can learn not only about mechanochemical synthesis but also about new reactions and syntheses of new compounds that could not be obtained under solution conditions. Recently, mechanochemical synthesis has become increasingly popular among a wide range of researchers as an environmentally friendly and highly efficient method, so this thesis has a timely publication. Chemistry, Organic. 65325 Chemistry. Reaction mechanisms (Chemistry). 66772 Green chemistry. 65085 Catalysis. 66843 Organic Chemistry. 65327 Chemical Synthesis. 68822 Reaction Mechanisms. 66775 Green Chemistry. 65085 Catalysis. 66843 SpringerLink (Online service) Springer Nature eBook Printed edition: 9789819719907 Printed edition: 9789819719921 Printed edition: 9789819719938 Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5061 66370 https://doi.org/10.1007/978-981-97-1991-4 ZDB-2-CMS ZDB-2-SXC 61285 61285