03595nam a22005415i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001400172072001600186072002300202072001500225100008000240245010500320250001800425264007200443300006500515336002600580337002600606338003600632347002400668490007200692505077700764520089101541650003102432650001502463650004402478650002802522650002202550650003002572650003102602650003202633650002802665650002202693710003402715773002602749776003602775776003602811776003602847830007902883856004602962912001403008912001403022999001703036978-981-97-1991-4DE-He21320251030112610.0cr nn 008mamaa240702s2024    si |    s    |||| 0|eng d  a97898197199149978-981-97-1991-47 a10.1007/978-981-97-1991-42doi 4aQD241-441 7aPNN2bicssc 7aSCI0130402bisacsh 7aPNN2thema1 aSeo, Tamae.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut97991110aPalladium-Catalyzed Mechanochemical Cross-Coupling Reactionsh[electronic resource] /cby Tamae Seo.  a1st ed. 2024. 1aSingapore :bSpringer Nature Singapore :bImprint: Springer,c2024.  aX, 278 p. 383 illus., 321 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aSpringer Theses, Recognizing Outstanding Ph.D. Research,x2190-50610 a1. General Introduction -- 2. Olefin Accelerated Solid State C N Cross Coupling Using Mechanochemistry -- 3. Solid State Suzuki-Miyaura Cross Coupling Reactions Using Mechanochemistry -- 4. Tackling Solubility Issues in Organic Synthesis: Solid State Cross Coupling of Insoluble Aryl Halides -- 5. Solid State Cross Coupling Reactions of Insoluble Aryl Halides Under Polymer Assisted Grinding Conditions -- 6. Mechanochemistry Directed Ligand Design: Development of a High Performance Phosphine Ligand for Palladium Catalyzed Suzuki Miyaura Cross Coupling Reactions -- 7. Mechanochemical Monoarylation of Dihaloarenes Enabled by In Situ Crystallization -- 8. Metallamechanoredox: Force induced Nickel Catalyzed Arylamination Using Ball Milling and Piezoelectric Materials.  aIn this thesis, the author developed cross-coupling reactions that proceed in the solid state without using organic solvents, utilizing a mechanochemical synthesis method using a ball mill. Compared to conventional solution systems, the reactions realized a drastic reduction of chemical waste, a drastic acceleration of chemical reactions, and efficient transformations of insoluble compounds. The thesis demonstrates that mechanochemical synthesis method has the potential to revolutionize organic synthesis. Readers can learn not only about mechanochemical synthesis but also about new reactions and syntheses of new compounds that could not be obtained under solution conditions. Recently, mechanochemical synthesis has become increasingly popular among a wide range of researchers as an environmentally friendly and highly efficient method, so this thesis has a timely publication. 0aChemistry, Organic.965325 0aChemistry. 0aReaction mechanisms (Chemistry).966772 0aGreen chemistry.965085 0aCatalysis.96684314aOrganic Chemistry.96532724aChemical Synthesis.96882224aReaction Mechanisms.96677524aGreen Chemistry.96508524aCatalysis.9668432 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978981971990708iPrinted edition:z978981971992108iPrinted edition:z9789819719938 0aSpringer Theses, Recognizing Outstanding Ph.D. Research,x2190-506196637040uhttps://doi.org/10.1007/978-981-97-1991-4  aZDB-2-CMS  aZDB-2-SXC  c61285d61285