03843nam a22005415i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001600172072001700188072002300205072001600228245018700244250001800431264007200449300005400521336002600575337002600601338003600627347002400663490007000687505114100757520060001898650002302498650003102521650003002552650002602582650002302608650003202631650002602663650003202689700008202721700008102803700008102884710003402965773002602999776003603025776003603061776003603097830007703133856004603210912001403256912001403270999001703284978-981-97-0511-5DE-He21320251030112616.0cr nn 008mamaa240705s2024    si |    s    |||| 0|eng d  a97898197051159978-981-97-0511-57 a10.1007/978-981-97-0511-52doi 4aQR180-189.5 7aMJCM2bicssc 7aMED0440002bisacsh 7aMJCM2thema10aNon B cell-Derived Immunoglobulinsh[electronic resource] :bThe Structure, Characteristics and the Implication on Clinical Medicine /cedited by Xiaoyan Qiu, Jing Huang, Xiaojun Xu.  a1st ed. 2024. 1aSingapore :bSpringer Nature Singapore :bImprint: Springer,c2024.  aXIV, 188 p. 31 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aAdvances in Experimental Medicine and Biology,x2214-8019 ;v14450 aChapter 1 The history of appreciation of immunoglobulin and the discovery of non-B cell derived immunoglobulins -- Chapter 2 Expression profile of non B-Ig in different lineage cells -- Chapter 3 Unique V(D)J recombination characteristics and repertoire of non B-Ig -- Chapter 4 Unique regulation mechanismof non B-Ig gene -- Chapter 5 Unique structure and function of non B-Ig -- Chapter 6 Comparison of non B-Ig and B-Ig -- Chapter 7 Functionsand clinical relevanceof non-B cell derived immunoglobulin in liver -- Chapter 8 Significance of non-Bcell derived immunoglobulins in renal disease -- Chapter 9 Functions and clinical significance of myocardial cell-derived Immunoglobulins -- Chapter 10 Biological functions and clinical significance of intestinal non B-Immunoglobulins -- Chapter 11 Function of IgG and IgA in normal human skin -- Chapter 12 Significance of cancer-derived IgG in lung cancer -- Chapter 13 Significance of cancer-derived IgG in breast cancer -- Chapter 14 Significance of cancer-derived IgG in pancreatic cancer -- Chapter 15 Biological functions and clinical significance of non B-Ig in hemopoietic system.  aThis book has expanded classic concept of immunology. Immunoglobulins have been widely discovered to be produced by many non-B cells. The non B cell-derived Igs display multifunction, which not only includes antibody activities and cellular biological functions under physiological conditions, but also directly participate in the pathological process of malignant tumour and immune-related diseases. This book provides new perspectives and a solid foundation for medical students, basic and clinical scientists to re-understand and broaden the physiological and pathological significance of Ig. 0aImmunology.969214 0aMedicinexResearch.962598 0aBiologyxResearch.965629 0aLife sciences.96507214aImmunology.96921424aBiomedical Research.96563324aLife Sciences.96507224aBiomedical Research.9656331 aQiu, Xiaoyan.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9801121 aHuang, Jing.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9801131 aXu, Xiaojun.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9801142 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978981970510808iPrinted edition:z978981970512208iPrinted edition:z9789819705139 0aAdvances in Experimental Medicine and Biology,x2214-8019 ;v144596783140uhttps://doi.org/10.1007/978-981-97-0511-5  aZDB-2-SBL  aZDB-2-SXB  c61382d61382