03390nam a22005295i 4500 978-981-97-3637-9 DE-He213 20251030112619.0 cr nn 008mamaa 240708s2024 si | s |||| 0|eng d 9789819736379 978-981-97-3637-9 10.1007/978-981-97-3637-9 doi R1 MB bicssc MED000000 bisacsh MB thema Bennett, Gabriel. author. aut http://id.loc.gov/vocabulary/relators/aut 75288 Senotherapy [electronic resource] : A Potential Pharmacological Strategy for Prolonging Human Lifespan and Healthspan / by Gabriel Bennett. 1st ed. 2024. Singapore : Springer Nature Singapore : Imprint: Springer, 2024. XVII, 100 p. 16 illus., 11 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda SpringerBriefs in Modern Perspectives on Disability Research, 3004-9717 Chapter 1. Introduction to Senotherapies -- Chapter 2. The Accumulation of Senescent Cells and Disease -- Chapter 3. Current Research about Senotheraputics -- Chapter 4. Final Comments -- Appendices. Historically, ageing has been regarded as a biological process that is unalterable. Although it is not possible to halt or reverse this process, medical scientists are currently attempting to extend lifespan and healthspan by developing treatments that ensure that the hallmarks of ageing do not resemble someone who is elderly. The accumulation of senescent cells is a hallmark of biological ageing. It is speculated that once the volume of senescent cells exceeds a safe therapeutic threshold the possibility of developing age-associated diseases increases. Senotherapeutic medications, otherwise known as senotherapy, aim to keep the volume of senescent cells below this threshold. These medications either eliminate senescent cells (i.e., senolytic medications) or prevent healthy cells from becoming senescent (i.e., senomorphic medications). While preliminary research shows that senotherapy is a promising strategy for increasing both human lifespan and healthspan, there nevertheless remains many unanswered questions. This book summarises our current research about senescent cell accumulation and age-associated diseases, human trials of senotherapeutic medications, and topics about senotherapy that require more research. Medical sciences. 65984 Pharmacology. 67844 Public health. 61312 Health Sciences. 65987 Pharmacology. 67844 Public Health. 61312 SpringerLink (Online service) Springer Nature eBook Printed edition: 9789819736362 Printed edition: 9789819736386 SpringerBriefs in Modern Perspectives on Disability Research, 3004-9717 75290 https://doi.org/10.1007/978-981-97-3637-9 ZDB-2-SLS ZDB-2-SXS 61432 61432