03199nam a22004815i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050000700172072001500179072002300194072001400217100008600231245014700317250001800464264007200482300006600554336002600620337002600646338003600672347002400708490007700732505020400809520123801013650002902251650002502280650002602305650002802331650002502359650002602384710003402410773002602444776003602470776003602506830008402542856004602626912001402672912001402686999001702700978-981-97-3637-9DE-He21320251030112619.0cr nn 008mamaa240708s2024    si |    s    |||| 0|eng d  a97898197363799978-981-97-3637-97 a10.1007/978-981-97-3637-92doi 4aR1 7aMB2bicssc 7aMED0000002bisacsh 7aMB2thema1 aBennett, Gabriel.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut97528810aSenotherapyh[electronic resource] :bA Potential Pharmacological Strategy for Prolonging Human Lifespan and Healthspan /cby Gabriel Bennett.  a1st ed. 2024. 1aSingapore :bSpringer Nature Singapore :bImprint: Springer,c2024.  aXVII, 100 p. 16 illus., 11 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aSpringerBriefs in Modern Perspectives on Disability Research,x3004-97170 aChapter 1. Introduction to Senotherapies -- Chapter 2. The Accumulation of Senescent Cells and Disease -- Chapter 3. Current Research about Senotheraputics -- Chapter 4. Final Comments -- Appendices.  aHistorically, ageing has been regarded as a biological process that is unalterable. Although it is not possible to halt or reverse this process, medical scientists are currently attempting to extend lifespan and healthspan by developing treatments that ensure that the hallmarks of ageing do not resemble someone who is elderly. The accumulation of senescent cells is a hallmark of biological ageing. It is speculated that once the volume of senescent cells exceeds a safe therapeutic threshold the possibility of developing age-associated diseases increases. Senotherapeutic medications, otherwise known as senotherapy, aim to keep the volume of senescent cells below this threshold. These medications either eliminate senescent cells (i.e., senolytic medications) or prevent healthy cells from becoming senescent (i.e., senomorphic medications). While preliminary research shows that senotherapy is a promising strategy for increasing both human lifespan and healthspan, there nevertheless remains many unanswered questions. This book summarises our current research about senescent cell accumulation and age-associated diseases, human trials of senotherapeutic medications, and topics about senotherapy that require more research. 0aMedical sciences.965984 0aPharmacology.967844 0aPublic health.96131214aHealth Sciences.96598724aPharmacology.96784424aPublic Health.9613122 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978981973636208iPrinted edition:z9789819736386 0aSpringerBriefs in Modern Perspectives on Disability Research,x3004-971797529040uhttps://doi.org/10.1007/978-981-97-3637-9  aZDB-2-SLS  aZDB-2-SXS  c61432d61432