03144nam a22004455i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001600153072001700169072002300186072001600209100008000225245013800305250001800443264007500461300006400536336002600600337002600626338003600652347002400688505039500712520124501107650001602352650001202368650001402380650002902394650001602423650002002439650002702459650003402486710003402520773002602554776003602580776003602616856004602652978-3-031-59866-1DE-He21320251030112624.0cr nn 008mamaa240712s2024    sz |    s    |||| 0|eng d  a97830315986617 a10.1007/978-3-031-59866-12doi 4aQR180-189.5 7aMJCM2bicssc 7aMED0440002bisacsh 7aMJCM2thema1 aGarrido, Federico.eauthor.4aut4http://id.loc.gov/vocabulary/relators/aut14aThe Major Histocompatibility Complex (MHC/ HLA) in Medicineh[electronic resource] :bA Personal Recollection /cby Federico Garrido.  a1st ed. 2024. 1aCham :bSpringer International Publishing :bImprint: Springer,c2024.  aXI, 108 p. 55 illus., 47 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aChapter 1: The discovery of the Major Histocompatibility Complex (MHC): The H-2 in mice and the HLA in humans -- Chapter 2: The discovery of the biological function of the MHC -- Chapter 3: HLA genes and molecules -- Chapter 4: HLA in transplantation -- Chapter 5: HLA class-I loss and cancer Immune escape -- Chapter 6: HLA and disease association -- Chapter 7: HLA in population genetics.  aThis book takes the reader on a journey through past and current research on the Major Histocompatibility Complex (MHC/HLA). It describes how it was discovered, what its biological function is and its application in medicine. The reader will learn about the molecular structure of the encoded molecules and different aspects of their role in medicine, including organ transplantation, their link to autoimmune diseases, cancer immunity, resistance to infectious diseases, and other related scientific areas, such as population genetics. In particular, the book focusses on the impact of MHC/HLA altered expression in tumours and their relevance in cancer immune escape and immunotherapy. It contains a large number of original figures and photographs of pioneers in the field, who made seminal contributions. Each chapter is supported by relevant key publications and enriched with a personal account of the early research that has contributed to our current understanding of the role of the major histocompatibility complex. This book is an excellent resource for all scientists in the biomedical life sciences who wish to gain insight into the discovery of the MHC/HLA and the role of this important genetic complex in health and disease. 0aImmunology. 0aCancer. 0aGenetics. 0aCancerxGenetic aspects.14aImmunology.24aCancer Biology.24aGenetics and Genomics.24aCancer Genetics and Genomics.2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303159865408iPrinted edition:z978303159867840uhttps://doi.org/10.1007/978-3-031-59866-1