03554nam a22005415i 4500 978-3-031-59866-1 DE-He213 20251030112624.0 cr nn 008mamaa 240712s2024 sz | s |||| 0|eng d 9783031598661 978-3-031-59866-1 10.1007/978-3-031-59866-1 doi QR180-189.5 MJCM bicssc MED044000 bisacsh MJCM thema Garrido, Federico. author. aut http://id.loc.gov/vocabulary/relators/aut 80421 The Major Histocompatibility Complex (MHC/ HLA) in Medicine [electronic resource] : A Personal Recollection / by Federico Garrido. 1st ed. 2024. Cham : Springer International Publishing : Imprint: Springer, 2024. XI, 108 p. 55 illus., 47 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Chapter 1: The discovery of the Major Histocompatibility Complex (MHC): The H-2 in mice and the HLA in humans -- Chapter 2: The discovery of the biological function of the MHC -- Chapter 3: HLA genes and molecules -- Chapter 4: HLA in transplantation -- Chapter 5: HLA class-I loss and cancer Immune escape -- Chapter 6: HLA and disease association -- Chapter 7: HLA in population genetics. This book takes the reader on a journey through past and current research on the Major Histocompatibility Complex (MHC/HLA). It describes how it was discovered, what its biological function is and its application in medicine. The reader will learn about the molecular structure of the encoded molecules and different aspects of their role in medicine, including organ transplantation, their link to autoimmune diseases, cancer immunity, resistance to infectious diseases, and other related scientific areas, such as population genetics. In particular, the book focusses on the impact of MHC/HLA altered expression in tumours and their relevance in cancer immune escape and immunotherapy. It contains a large number of original figures and photographs of pioneers in the field, who made seminal contributions. Each chapter is supported by relevant key publications and enriched with a personal account of the early research that has contributed to our current understanding of the role of the major histocompatibility complex. This book is an excellent resource for all scientists in the biomedical life sciences who wish to gain insight into the discovery of the MHC/HLA and the role of this important genetic complex in health and disease. Immunology. 69214 Cancer. 4311 Genetics. 68863 Cancer Genetic aspects. 73501 Immunology. 69214 Cancer Biology. 67829 Genetics and Genomics. 68866 Cancer Genetics and Genomics. 73502 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031598654 Printed edition: 9783031598678 https://doi.org/10.1007/978-3-031-59866-1 ZDB-2-SBL ZDB-2-SXB 61530 61530