03612nam a22006255i 4500 978-3-031-62604-3 DE-He213 20251030112627.0 cr nn 008mamaa 240713s2024 sz | s |||| 0|eng d 9783031626043 978-3-031-62604-3 10.1007/978-3-031-62604-3 doi RM300-666 RM300-666 MMG bicssc MMG bicssc MED071000 bisacsh MKG thema MKG thema CNS Drug Development and Delivery [electronic resource] : Concepts and Applications / edited by Alan Talevi. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. VII, 230 p. 24 illus., 22 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda AAPS Introductions in the Pharmaceutical Sciences, 2522-8358 ; 9999 Chapter 1- Transporter-mediated drug delivery to the brain -- Chapter 2 - Mechanisms and methods for evaluating drug delivery via transcytosis to the brain -- Chapter 3 -In vitro blood-brain studies -- Chapter 4 - In silico prediction of CNS bioavailability -- Chapter 5 - Use of unbound exposure data to establish in vitro-in vivo correlations for CNS drug candidates -- Chapter 6 - Intranasal Delivery of Drugs to the Central Nervous System -- Chapter 7 - Polymeric nanoparticles for nose-to-brain delivery in Alzheimer's and Parkinson´s diseases -- Chapter 8 - Barriers of the CNS and their contribution to drug-resistant epilepsy -- Chapter 9 - Network-pharmacology and central nervous system drug development. The book covers recent advances in the field of CNS therapeutics, including opportunities posed by expanding basic knowledge related to CNS conditions and novel approaches for efficient drug delivery to the brain (e.g., pharmaceutical nanocarriers and transporter- and transcytosis-mediated drug delivery to the brain inhibition of the blood-brain barrier). Chapters dealing with state-of-the-art in silico and in vitro tools for predictive purposes related to CNS bioavailability are also be included. This is an ideal book for undergraduate students and graduates in the field of medicine and pharmaceutics, and professionals working in the field of brain disorders. Pharmacology. 67844 Neuropharmacology. 78368 Drug delivery systems. Pharmaceutical chemistry. 67843 Pharmacology. 67844 Pharmacology. 67844 Neuropharmacology. 78368 Drug Delivery. 69429 Pharmaceutics. 67846 Talevi, Alan. editor. edt http://id.loc.gov/vocabulary/relators/edt 74085 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031626036 Printed edition: 9783031626050 Printed edition: 9783031626067 AAPS Introductions in the Pharmaceutical Sciences, 2522-8358 ; 9999 71123 https://doi.org/10.1007/978-3-031-62604-3 ZDB-2-SBL ZDB-2-SXB 61567 61567