03371nam a22005655i 4500001001800000003000900018005001700027007001500044008004100059020003700100024003500137050001400172050001400186072001600200072001600216072002300232072001500255072001500270245011600285250001800401264006900419300006500488336002600553337002600579338003600605347002400641490007400665505072000739520067301459650002502132650003002157650002702187650003702214650002502251650002502276650003002301650002602331650002602357700008202383710003402465773002602499776003602525776003602561776003602597830008102633856004602714912001402760912001402774999001702788978-3-031-62604-3DE-He21320251030112627.0cr nn 008mamaa240713s2024    sz |    s    |||| 0|eng d  a97830316260439978-3-031-62604-37 a10.1007/978-3-031-62604-32doi 4aRM300-666 4aRM300-666 7aMMG2bicssc 7aMMG2bicssc 7aMED0710002bisacsh 7aMKG2thema 7aMKG2thema10aCNS Drug Development and Deliveryh[electronic resource] :bConcepts and Applications /cedited by Alan Talevi.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aVII, 230 p. 24 illus., 22 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aAAPS Introductions in the Pharmaceutical Sciences,x2522-8358 ;v99990 aChapter 1- Transporter-mediated drug delivery to the brain -- Chapter 2 - Mechanisms and methods for evaluating drug delivery via transcytosis to the brain -- Chapter 3 -In vitro blood-brain studies -- Chapter 4 - In silico prediction of CNS bioavailability -- Chapter 5 - Use of unbound exposure data to establish in vitro-in vivo correlations for CNS drug candidates -- Chapter 6 - Intranasal Delivery of Drugs to the Central Nervous System -- Chapter 7 - Polymeric nanoparticles for nose-to-brain delivery in Alzheimer's and Parkinson´s diseases -- Chapter 8 - Barriers of the CNS and their contribution to drug-resistant epilepsy -- Chapter 9 - Network-pharmacology and central nervous system drug development.  aThe book covers recent advances in the field of CNS therapeutics, including opportunities posed by expanding basic knowledge related to CNS conditions and novel approaches for efficient drug delivery to the brain (e.g., pharmaceutical nanocarriers and transporter- and transcytosis-mediated drug delivery to the brain inhibition of the blood-brain barrier). Chapters dealing with state-of-the-art in silico and in vitro tools for predictive purposes related to CNS bioavailability are also be included. This is an ideal book for undergraduate students and graduates in the field of medicine and pharmaceutics, and professionals working in the field of brain disorders. 0aPharmacology.967844 0aNeuropharmacology.978368 0aDrug delivery systems. 0aPharmaceutical chemistry.96784314aPharmacology.96784424aPharmacology.96784424aNeuropharmacology.97836824aDrug Delivery.96942924aPharmaceutics.9678461 aTalevi, Alan.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt9740852 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303162603608iPrinted edition:z978303162605008iPrinted edition:z9783031626067 0aAAPS Introductions in the Pharmaceutical Sciences,x2522-8358 ;v999997112340uhttps://doi.org/10.1007/978-3-031-62604-3  aZDB-2-SBL  aZDB-2-SXB  c61567d61567