05868nam a22006015i 4500 978-3-031-62731-6 DE-He213 20251030112634.0 cr nn 008mamaa 240717s2024 sz | s |||| 0|eng d 9783031627316 978-3-031-62731-6 10.1007/978-3-031-62731-6 doi QH450.2 PSD bicssc SCI029000 bisacsh PSD thema Transcription factors in blood cell development [electronic resource] / edited by Tilman Borggrefe, Benedetto Daniele Giaimo. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. XLIV, 430 p. 79 illus., 73 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Advances in Experimental Medicine and Biology, 2214-8019 ; 1459 Part 1 – Stem/Progenitor Cells -- Chapter 1. MYB - A Key Transcription Factor in the Hematopoietic System Subject to many Levels of Control - Roza Berhanu Lemma, Bettina Maria Fuglerud, Jon Frampton & Odd Stokke Gabrielsen -- Part 2 – T-Cells -- Chapter 2. Ikaros Family Transcription Factors in Lymphocyte Differentiation and Function - Philippe Kastner & Susan Chan -- Chapter 3. The Role of the Transcriptional Co-Activator BOB.1/OBF.1 in Adaptive Immunity - Annika C. Betzler & Cornelia Brunner -- Chapter 4. Key Functions of the Transcription Factor BCL6 during T-Cell Differentiation - Chara Konstantakopoulou & Mihalis Verykokakis -- Part 3 – B-Cells -- Chapter 5. The Function of E2A in B-Cell Development - Masaki Miyazaki & Kazuko Miyazaki -- Chapter 6. Hypoxia and the Hypoxia-Inducible Factors in Lymphocyte Differentiation and Function - Mark Boothby & Sung Hoon Cho -- Chapter 7. Early B-Cell Factor 1: An Archetype for a Lineage-Restricted Transcription Factor Linking Development to Disease - Mikael Sigvardsson -- Part 4 – Myeloid Cells -- Chapter 8. Transcription Factor NRF2 in Shaping Myeloid Cell Differentiation and Function - Marc Pfefferlé & Florence Vallelian -- Part 5 – Erythroid Cells -- Chapter 9. Trancriptional Repressor BCL11A In Erythroid Cells - Ge Zheng & Stuart H. Orkin -- Chapter 10. Erythroid Krüppel-like Factor / KLF1: a Surprisingly Versatile Regulator of Erythroid Differentiation - James J Bieker & Sjaak Philipsen -- Chapter 11. Transcription Factor TAL1 in Erythropoiesis - Johannes Fechner & Jörn Lausen -- Part 6 – Megakaryocytes -- Chapter 12. GATA1 in Normal and Pathologic Megakaryopoiesis and Platelet Development - Kaoru Takasaki & Stella T. Chou -- Part 7 – Leukemia/Lymphoma -- Chapter 13. The Diverse Roles of ETV6 Alterations in B-Lymphoblastic Leukemia and other Hematopoietic Cancers - Alexander C. Monovich, Aishwarya Gurumurthy & Russell J.H. Ryan -- Chapter 14. Function of PML-RARA in Acute Promyelocytic Leukemia - Ugo Testa & Elvira Pelosi -- Cha[ter 15. MYB as a Critical Transcription Factor and Potential Therapeutic Target in AML - Mary Louise Clarke, Odd Stokke Gabrielsen & Jon Frampton -- Chapter 16. ETS1 Function in Leukemia and Lymphoma - Rebecca A. Luchtel -- Chapter 17. The Molecular and Biological Function of MEF2D in Leukemia - Pengcheng Zhang & Rui Lu -- Chapter 18. HOXA9 Regulome and Pharmacological Interventions in Leukemia - Sajesan Aryal & Rui Lu. This book describes transcription factors in the context of hematopoietic development and reveal mechanistic insights how they orchestrate specific gene expression patterns. Several examples from lymphoid and myeloid lineages are given as well as particular examples of leukemia fusion proteins that contain a part of a transcription factor. In the given chapters covering each one particular example, the function of transcription factors is characterized in normal as well as leukemic contexts. New technologies such as ChIP-Seq or RNA-Seq, that make use of genome-wide sequencing, have shown that such master regulators of blood cell development often work in combinatorial fashion and, when dysregulated, results in leukemogenesis. This book is not only intended for experts but it should also be a useful resource for younger scientists or scientists from other disciplines, who may use this book as a stimulating starting point for further discoveries and/ or translational endeavors. Genetic transcription. 80775 Cytology. 67436 Post-translational modification. 80776 Hematopoietic system. 80777 Developmental biology. 67434 Gene Transcription. 80778 Cell Biology. 67440 Post-translational Modifications. 80779 Haematopoietic System. 80780 Developmental Biology and Stem Cells. 67438 Borggrefe, Tilman. editor. (orcid)0000-0003-4325-5452 https://orcid.org/0000-0003-4325-5452 edt http://id.loc.gov/vocabulary/relators/edt 80781 Giaimo, Benedetto Daniele. editor. edt http://id.loc.gov/vocabulary/relators/edt 80782 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031627309 Printed edition: 9783031627323 Printed edition: 9783031627330 Advances in Experimental Medicine and Biology, 2214-8019 ; 1459 67831 https://doi.org/10.1007/978-3-031-62731-6 ZDB-2-SBL ZDB-2-SXB 61692 61692