03797nam a22004575i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001400153072001600167072002300183072001500206245018800221250001800409264007500427300006500502336002600567337002600593338003600619347002400655490007200679505055600751520155501307650001802862650001602880650001402896650002502910650002902935650001802964650002702982700008003009710003403089773002603123776003603149776003603185830007203221856004603293978-3-031-55163-5DE-He21320251030112637.0cr nn 008mamaa240719s2024    sz |    s    |||| 0|eng d  a97830315516357 a10.1007/978-3-031-55163-52doi 4aQP251-285 7aPSA2bicssc 7aSCI0560002bisacsh 7aPSA2thema10aMolecular Mechanisms Determining Mammalian Oocyte Qualityh[electronic resource] :bOocyte Developmental Competence, Aneuploidy, and Clinical Relevance /cedited by Ahmed Z. Balboula.  a1st ed. 2024. 1aCham :bSpringer International Publishing :bImprint: Springer,c2024.  aVII, 129 p. 19 illus., 18 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aAdvances in Anatomy, Embryology and Cell Biology,x2192-7065 ;v2380 aChapter 1. Predicting Infertility: How Genetic Variants in Oocyte Spindle Genes Affect Egg Quality -- Chapter 2. Regulation of Oocyte mRNA Metabolism: A Key Determinant of Oocyte Developmental Competence -- Chapter 3. Mechanisms of DNA Damage Response in Mammalian Oocytes -- Chapter 4. How do Environmental Toxicants Affect Oocyte Maturation via Oxidative Stress? -- Chapter 5. Molecular Mechanisms Determining Mammalian Oocyte Quality with the Treatment of Cancer Therapy -- Chapter 6. Telomere Elongation during Pre-implantation Embryo Development.  aAs the age of childbearing increases, reduced female gamete (egg) quality has emerged as the primaery cause of infertility in women. This book addresses molecular mechanisms that regulate oocyte quality as well as intrinsic and extrinsic factors that compromise these mechanisms. Eggs are produced through a unique cell division called meiosis. Oocyte meiosis is initiated early in fetal life. Shortly before birth, the oocyte undergoes a prolonged arrest at prophase I until the age of puberty, at which selected oocytes resume meiosis I. Following meiotic resumption and during oocyte maturation, tight regulation of nuclear and DNA-related mechanisms ensures proper homologous chromosome segregation prior to another arrest at metaphase II. Any errors prior to completion of meiosis I can lead to chromosome segregation errors and aneuploidy, the most common genetic cause of miscarriage and congenital disorders such as Down syndrome. In addition to nuclear maturation, several cytoplasmic processes are orchestrated to support cell division and to generate developmentally competent eggs capable of supporting fertilization and early embryonic development. The interaction between these nuclear and cytoplasmic processes is critical for producing good-quality oocytes. This volume in the Advances in Anatomy, Embryology and Cell Biology book series presents current reviews by leading experts. It offers valuable insights for researchers, physicians and Ph.D. students interested in reproductive biology, particularly oocyte quality and meiosis. 0aReproduction. 0aPhysiology. 0aCytology. 0aReproductive health.14aReproductive Physiology.24aCell Biology.24aReproductive Medicine.1 aBalboula, Ahmed Z.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303155162808iPrinted edition:z9783031551642 0aAdvances in Anatomy, Embryology and Cell Biology,x2192-7065 ;v23840uhttps://doi.org/10.1007/978-3-031-55163-5