05321nam a22006135i 4500 978-3-031-61257-2 DE-He213 20251030112643.0 cr nn 008mamaa 240723s2024 sz | s |||| 0|eng d 9783031612572 978-3-031-61257-2 10.1007/978-3-031-61257-2 doi QH506 PSD bicssc SCI049000 bisacsh PSD thema Carlberg, Carsten. author. (orcid)0000-0003-2633-0684 https://orcid.org/0000-0003-2633-0684 aut http://id.loc.gov/vocabulary/relators/aut 81052 Aging [electronic resource] : How Science Works / by Carsten Carlberg, Stine M. Ulven, Eunike Velleuer. 1st ed. 2024. Cham : Springer Nature Switzerland : Imprint: Springer, 2024. XV, 175 p. 79 illus., 78 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda 1. The human genome, development and evolution -- 2. Gene expression and epigenetics -- 3. Epigenetics and aging -- 4. Molecular and cellular basis of aging -- 5. Nutrition and aging -- 6. Aging and immunity -- 7. Central role of aging during chronic diseases -- 8. Aging and cancer -- 9. Healthy aging. Aging is a topic that concerns all of us, since none of us can escape it. The molecular and cellular process is built in every of the billions of cells forming our body. Some of these cells, such as immune cells and red blood cells, live only for a few days to weeks and get life-long constantly replaced by cells produced in the bone marrow. In contrast, there are cells, such as neurons and memory lymphocytes, that get as old as we get. The process of aging limits our maximal life span, which is for our humans 120 years. However, only a very few individuals reached this age. How did their life differ from others that died decades earlier? Is it just the absence of life threatening disease paired with a more healthy life style? Or is it build in in our genome or epigenome? In this book we try to give answers to these questions from the perspectives of evolution, our genome, the epigenomes of our different tissues and cell types and the functionality of our cells. We should try to understand ourselves in detail as well as in a global setting. Basic biology explains cellular mechanisms, such as growth, differentiation, and cell death, which make life as a whole possible. Every (human) organism represents a complex interplay between hundreds of different cell types forming distinctive tissues and organs with specialized tasks. These processes need to be highly orchestrated especially during development, maintenance and aging. Studying the cellular and molecular basis of aging is one of the most fascinating areas but also a great challenge. Nevertheless, research made the biggest steps in elucidating biological processes via studying malfunctions of normal mechanisms leading to different diseases, such as progeroid syndrome and cancer. We will start this book with the understanding of the human genome in relation to principles of evolution. Then we will explain the basics of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin. Next, we will shift to cellular mechanisms of aging and discuss then the impact of nutrition and immunity on the aging process. In the following the relation of aging to so-called aging-related common diseases, such as type 2 diabetes, atherosclerosis, cancer and Alzheimer. Do we get these diseases because we are aging or are we aging because we get one of these diseases? The book will end how we can slow down the aging process so that we can age healthy. In short, healthy aging is not an option but is a must. An ancient poem says “Teach us to number our days, that we may get a heart of wisdom.” It is up to each one of us and a daily decision to live a healthy lifestyle and to be aware of the unique gift of live we all have. . Molecular biology. Epigenetics. 77287 Nutrition   . 68694 Molecular Evolution. 81053 Cancer. 4311 Metabolism. 2468 Molecular Biology. Epigenetics. 77287 Nutrition. 68694 Molecular Evolution. 81053 Cancer Biology. 67829 Metabolism. 2468 Ulven, Stine M. author. aut http://id.loc.gov/vocabulary/relators/aut 81054 Velleuer, Eunike. author. aut http://id.loc.gov/vocabulary/relators/aut 81055 SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031612565 Printed edition: 9783031612589 Printed edition: 9783031612596 https://doi.org/10.1007/978-3-031-61257-2 ZDB-2-SBL ZDB-2-SXB 61817 61817