03709nam a22004695i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001400153072001600167072002300183072001500206245016200221250001800383264006900401300006800470336002600538337002600564338003600590347002400626505120600650520086601856650002702722650001602749650002202765650002902787650002702816650003102843650002202874650002902896650001902925700008102944710003403025773002603059776003603085776003603121776003603157856004603193978-3-031-60044-9DE-He21320251030112655.0cr nn 008mamaa240728s2024    sz |    s    |||| 0|eng d  a97830316004497 a10.1007/978-3-031-60044-92doi 4aQP101-110 7aPSA2bicssc 7aSCI0560002bisacsh 7aPSA2thema10aIn Silico Clinical Trials for Cardiovascular Diseaseh[electronic resource] :bA Finite Element and Machine Learning Approach /cedited by Nenad Filipović.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aVIII, 426 p. 143 illus., 123 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda0 aChapter 1 - Heart physiology and heart diseases, Djordje Jakovljevic, Nenad Filipovic -- Chapter 2 - Finite element modeling, Nenad Filipovic -- Chapter 3 - System biology modeling for drug optimization, Marko Zivanovic, Nenad Filipovic -- Chapter 4 - Artificial intelligence approach for medical image processing, Tijana Sustersic, Nenad Filipovic.-Chapter 5 - Pharmacokinetic and AI modeling, Lazar Velicki, Nenad Filipovic -- Chapter 6 - Molecular micro modeling of heart muscle, Momcilo Prodanovic, Nenad Filipovic -- Chapter 7 - Use case: Risk stratification of cardiomyopathy disease, Lazar Dasic, Nenad Filipovic -- Chapter 8 - Use case: Surrogate AI model for left ventricle modeling, Bogdan Milicevic, Nenad Filipovic -- Chapter 9 - Use case: Carotid artery plaque modeling, Andjela Blagojevic, Nenad Filipovic -- Chapter 10 - Use case: Stent deployment for coronary artery, Miljan Milosevic, Nenad Filipovic -- Chapter 11 - Use case: Balloon deployment for peripheral arteries. Aleksandra Vulovic, Nenad Filipovic -- Chapter 12 - Use case: Aorta stenosis modeling, Smiljana Tomasevic, Nenad Filipovic -- Chapter 13 - Use case: Stent biodegradation modeling, Dalibor Nikolic, Nenad Filipovic.  aThis book covers in silico clinical trials of cardiovascular disease using a finite element and machine learning approach. Part I describes the fundamentals as well as the latest developments in the field: finite element modeling, system biology modeling for drug optimization, artificial intelligence approach for medical image processing, as well as pharmacokinetic and AI modeling. Part II provides use cases to describe how in silico clinical trials of cardiovascular disease are applied to specific cardiovascular diseases: carotid artery plaque modeling, aorta stenosis modeling, stent biodegradation modeling, surrogate AI model for left ventricle modeling, and more. This book is geared toward upper-level undergraduate and graduate students as well as for researchers in the domains of bioengineering, biomechanics, biomedical engineering and medicine. 0aCardiovascular system. 0aPhysiology. 0aMachine learning. 0aArtificial intelligence. 0aDrug delivery systems.14aCardiovascular Physiology.24aMachine Learning.24aArtificial Intelligence.24aDrug Delivery.1 aFilipović, Nenad.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303160043208iPrinted edition:z978303160045608iPrinted edition:z978303160046340uhttps://doi.org/10.1007/978-3-031-60044-9