04306nam a22005535i 4500001001800000003000900018005001700027007001500044008004100059020001800100024003500118050001400153050001400167072001600181072002300197072001500220245014600235250001800381264006900399300006500468336002600533337002600559338003600585347002400621490008100645505070500726520155901431650001402990650002503004650002703029650001603056650001603072650002303088650002103111650001803132650003103150650001603181650002303197700007903220700007803299700008003377710003403457773002603491776003603517776003603553776003603589830008103625856004603706978-3-031-62131-4DE-He21320251030112842.0cr nn 008mamaa240808s2024    sz |    s    |||| 0|eng d  a97830316213147 a10.1007/978-3-031-62131-42doi 4aQH573-671 4aQP82.2.S8 7aPSF2bicssc 7aSCI0170002bisacsh 7aPSF2thema10aOxidative Stress in Cardiovascular-Metabolic Diseasesh[electronic resource] /cedited by Ali Hussein Eid, Firas Kobeissy, Ahmed F. El-Yazbi.  a1st ed. 2024. 1aCham :bSpringer Nature Switzerland :bImprint: Springer,c2024.  aXII, 298 p. 39 illus., 38 illus. in color.bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  atext filebPDF2rda1 aOxidative Stress in Applied Basic Research and Clinical Practice,x2197-72320 aChapter 1 - Interplay between ROS and gender in the pathogenesis of cardiovascular disease -- chapter 2 -ROS, aging and cardiovascular disease -- Chapter 3 - Combat ROS, prevent CVD -- Chapter 4 -Traumatic-brain injury and CVD: ROS is the link? -- Chapter 5 - Adipose tissue inflammation and CVD: oxidative stress as a catalyst -- Chapter 6 - Oxidative stress in diabetes-compounded CVD -- Chapter 7 - ROS in hypertension: a critical update -- Chapter 8 - ROS in atherosclerosis: what we know.-Chapter 9 - ROS as a key mediator of cardiovasculometabolic disease -- Chapter 10 - Antioxidant Therapy in CVD: hope or hype? -- Chapter 11 - Antioxidants as adjuvant therapy: Evidence from clinical trials.  aThe book dissects the role of oxidative stress in the pathogenesis of the leading causes of global morbidity and mortality, i.e.cardiovascular and metabolic diseases. The chapters discuss topics related to the role reactive oxygen species (ROS) play in hypertension, atherosclerosis,diabetes, obesity and related pathologies. The authors also shed light on gender differences in the onset and pathologies of some of these diseases. Moreover, how ROS and aging interplay to precipitate cardiovasculo-metabolic disease is discussed and highlighted. Preventive measures that can abrogate ROS-induced cardiovasclo-metabolic disease are discussed and clarified in the hope of reducing such a debilitating battery of diseases. A section dedicated to antioxidants as potential therapy is also included. Furthermore, given the complexity of the mechanisms implicated in ROS-modulated responses, it remains challenging to assert a conclusive argument and pre-determined regimen for incorporating antioxidants into conventional therapies. Nonetheless, results from some clinical trials appear promising, warranting the addition of a chapter dedicated to such human trials. In all of the chapters, the molecular, cellular, genetic, and pharmacological mechanisms implicated are covered from an applied science perspective. This is an ideal book for basic researchers in the biomedical field, graduate students in biological and biomedical fields, medical students, instructors in medical and graduate schools, and professionals working for pharmaceutical companies. 0aCytology. 0aStress (Physiology). 0aCardiovascular system. 0aPhysiology. 0aMetabolism. 0aMolecular biology.14aCellular Stress.24aCell Biology.24aCardiovascular Physiology.24aMetabolism.24aMolecular Biology.1 aEid, Ali Hussein.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt1 aKobeissy, Firas.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt1 aEl-Yazbi, Ahmed F.eeditor.4edt4http://id.loc.gov/vocabulary/relators/edt2 aSpringerLink (Online service)0 tSpringer Nature eBook08iPrinted edition:z978303162130708iPrinted edition:z978303162132108iPrinted edition:z9783031621338 0aOxidative Stress in Applied Basic Research and Clinical Practice,x2197-723240uhttps://doi.org/10.1007/978-3-031-62131-4